138-92-1
Chemical Structure
Betazole dihydrochloride
Synonym(s): Ametazole dihydrochloride
- CAS No.: 138-92-1
- Formula:C5H11Cl2N3
- Molecular Weight:184.07
IUPAC Name: 2-(1H-pyrazol-3-yl)ethan-1-amine dihydrochloride
InChIKey: BUXCUOWXTOKEMQ-UHFFFAOYSA-N
SMILES: NCCC1=NNC=C1.[H]Cl.[H]Cl
Biological Activity: Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].
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Betazole dihydrochloride | Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity. | |||||||||||||||||||||
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- [1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [Content Brief]
- [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [Content Brief]
- [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909. [Content Brief]
Keywords
