1. TGF-beta/Smad
  2. TGF-β Receptor
  3. BIO-013077-01

BIO-013077-01 

Cat. No.: HY-118810
Handling Instructions

BIO-013077-01 is a pyrazole TGF-β inhibitor.

For research use only. We do not sell to patients.

BIO-013077-01 Chemical Structure

BIO-013077-01 Chemical Structure

CAS No. : 746667-48-1

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Description

BIO-013077-01 is a pyrazole TGF-β inhibitor[1].

In Vitro

A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies[1].

In Vivo

TGF-β Inhibitor

Molecular Weight

287.32

Formula

C₁₇H₁₃N₅

CAS No.

746667-48-1

SMILES

CC1=CC=CC(C2=NNC=C2C3=CC=C4N=CC=NC4=C3)=N1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BIO-013077-01TGF-β ReceptorTransforming growth factor beta receptorsAlkylationpyrazolesALK5fibrosisautophosphorylationInhibitorinhibitorinhibit

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