Propyphenazone (Synonyms: 4-Isopropylantipyrine; Isopropylphenazone)

Cat. No.: HY-A0273 Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions

Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

For research use only. We do not sell to patients.

Propyphenazone Chemical Structure

CAS No. : 479-92-5

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Free Sample (0.1 - 0.5 mg)		Apply Now
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10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
250 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
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COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
Customer Review

Description

Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. Target：COX-2 Propyphenazone is structurally related to aminophenazone it has been associated with severe blood dyscrasias. Propyphenazone is introduced for the treatment of rheumatic disorders.

IC₅₀ & Target

COX

Molecular Weight

230.31

Appearance

Solid

Formula

C₁₄H₁₈N₂O

CAS No.

479-92-5

SMILES

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1C(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 2.6 mg/mL (11.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3420 mL	21.7099 mL	43.4197 mL
5 mM	0.8684 mL	4.3420 mL	8.6839 mL
10 mM	0.4342 mL	2.1710 mL	4.3420 mL

*Please refer to the solubility information to select the appropriate solvent.

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (253 KB) HNMR (286 KB) LCMS (119 KB)

Handling Instructions (2659 KB)

References

[1]. Burdan F, et al. Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration. Cells Tissues Organs. 2002;171(2-3):145-51. [Content Brief]

Propyphenazone Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Propyphenazone479-92-54-Isopropylantipyrine IsopropylphenazoneCOXCyclooxygenaseInhibitorinhibitorinhibit

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