1-Methyl-1H-pyrazole-4-boronic acid pinacol ester
Based on 1 Customer Validation
1-Methyl-1H-pyrazole-4-boronic acid pinacol ester is an organic synthetic intermediate, which can be used to synthesize other active compounds.
For research use only. We do not sell to patients.
- Purity : 99.70%
- CAS No.: 761446-44-0
- Formula: C10H17BN2O2
- Molecular Weight:208.07
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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4-(Carboxymethyl)phenylboronic acid pinacol ester
Biological Activity
Description
In Vitro
1-Methyl-1H-pyrazole-4-boronic acid pinacol ester can participate in the synthesis of pyrrolo[2,1-f][1,2,4]triazine derivatives through Suzuki coupling reaction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 761446-44-0
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Appearance Solid
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Molecular Weight 208.07
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Formula C10H17BN2O2
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Color Off-white to light yellow
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SMILES
CC1(C)C(C)(C)OB(C2=CN(C)N=C2)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (480.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.02 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.02 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8061 mL | 24.0304 mL | 48.0607 mL | 120.1519 mL |
| 5 mM | 0.9612 mL | 4.8061 mL | 9.6121 mL | 24.0304 mL | |
| 10 mM | 0.4806 mL | 2.4030 mL | 4.8061 mL | 12.0152 mL | |
| 15 mM | 0.3204 mL | 1.6020 mL | 3.2040 mL | 8.0101 mL | |
| 20 mM | 0.2403 mL | 1.2015 mL | 2.4030 mL | 6.0076 mL | |
| 25 mM | 0.1922 mL | 0.9612 mL | 1.9224 mL | 4.8061 mL | |
| 30 mM | 0.1602 mL | 0.8010 mL | 1.6020 mL | 4.0051 mL | |
| 40 mM | 0.1202 mL | 0.6008 mL | 1.2015 mL | 3.0038 mL | |
| 50 mM | 0.0961 mL | 0.4806 mL | 0.9612 mL | 2.4030 mL | |
| 60 mM | 0.0801 mL | 0.4005 mL | 0.8010 mL | 2.0025 mL | |
| 80 mM | 0.0601 mL | 0.3004 mL | 0.6008 mL | 1.5019 mL | |
| 100 mM | 0.0481 mL | 0.2403 mL | 0.4806 mL | 1.2015 mL |
1-Methyl-1H-pyrazole-4-boronic acid pinacol ester Related Classifications
HY-I0308 Related Classifications
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