Pyrimidine-5-boronic acid pinacol ester

Name: Pyrimidine-5-boronic acid pinacol ester
Brand: MedChemExpress
SKU: HY-42045
Rating: 4.5 (1 reviews)

Cat. No.: HY-42045 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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Pyrimidine-5-boronic acid pinacol ester is a derivative of Boronic acid. Boronic acid is an intermediate commonly used in organic synthesis reactions and can be used as a key reagent in the Suzuki-Miyaura reaction. It generates organic free radicals through oxygen-mediated oxidation and exhibits potential mutagenic activity. Boronic acid is mainly used in research in the fields of drug synthesis and catalytic reactions. Pyrimidine-5-boronic acid pinacol ester serves as a building block in DNA-compatible one-pot click chemistry for synthesis of DNA-encoded libraries.

For research use only. We do not sell to patients.

Pyrimidine-5-boronic acid pinacol ester Chemical Structure

CAS No. : 321724-19-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

In Vitro

Pyrimidine-5-boronic acid pinacol ester (400 mM; 4 h) undergoes a DNA-compatible one-pot click reaction with DNA-conjugated terminal alkyne to form a DNA-conjugated 1,2,3-triazole^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

206.05

Formula

C₁₀H₁₅BN₂O₂

CAS No.

321724-19-0

Appearance

Solid

Color

White to off-white

SMILES

CC1(C)OB(C2=CN=CN=C2)OC1(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (485.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8532 mL	24.2660 mL	48.5319 mL
5 mM	0.9706 mL	4.8532 mL	9.7064 mL
10 mM	0.4853 mL	2.4266 mL	4.8532 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (274 KB) SDS (396 KB)

COA (253 KB) HNMR (128 KB)

Handling Instructions (2659 KB)

References

[1]. An Y, et al. DNA-Compatible Click Reaction Employing In Situ Generated Azides from Boronic Acids. Curr Protoc. 2021;1(5):e125.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8532 mL	24.2660 mL	48.5319 mL	121.3298 mL
	5 mM	0.9706 mL	4.8532 mL	9.7064 mL	24.2660 mL
	10 mM	0.4853 mL	2.4266 mL	4.8532 mL	12.1330 mL
	15 mM	0.3235 mL	1.6177 mL	3.2355 mL	8.0887 mL
	20 mM	0.2427 mL	1.2133 mL	2.4266 mL	6.0665 mL
	25 mM	0.1941 mL	0.9706 mL	1.9413 mL	4.8532 mL
	30 mM	0.1618 mL	0.8089 mL	1.6177 mL	4.0443 mL
	40 mM	0.1213 mL	0.6066 mL	1.2133 mL	3.0332 mL
	50 mM	0.0971 mL	0.4853 mL	0.9706 mL	2.4266 mL
	60 mM	0.0809 mL	0.4044 mL	0.8089 mL	2.0222 mL
	80 mM	0.0607 mL	0.3033 mL	0.6066 mL	1.5166 mL
	100 mM	0.0485 mL	0.2427 mL	0.4853 mL	1.2133 mL