SHMT
Serine hydroxymethyltransferase
Serine hydroxymethyltransferase (SHMT) catalyzes a series of reactions, such as the reversible interconversion of serine and glycine, the H4PteGlu-independent cleavage of 3-hydroxyamino acids, and the decarboxylation of aminomalonate.
SHMT plays an important role in one-carbon metabolism and it's expression is associated with tumor growth and prognosis. In addition, SHMT is considered a biological target enzyme of the parasite malaria.
SHMT plays an important role in one-carbon metabolism and it's expression is associated with tumor growth and prognosis. In addition, SHMT is considered a biological target enzyme of the parasite malaria.
SHMT Isoform Specific Products
All Product Categories
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SHMT Related Products (13)
Related Products (13)
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SHMT Isoform Comparison
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SHIN1
0 ImagesSynonyms: RZ-2994SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.
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(+)SHIN2
0 Images(+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, whose target can be traced with 13C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519). (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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(Rac)-SHIN2
0 Images(Rac)-SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac)-SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac)-SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus.
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(+)-SHIN1
0 ImagesSynonyms: (+)-RZ-2994(+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1.
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AGF347
0 ImagesCat. No.: HY-177092CAS No.: 2294820-23-6AGF347 is a one-carbon/purine biosynthesis inhibitor. AGF347 inhibits SHMT1/2 serine hydroxymethyltransferase and GARFTase/AICARFTase de novo purine formyltransferases, with target Ki values of 2.91 µM, 2.19 µM, 3.13 µM, and 3.72 µM, respectively. AGF347 depletes adenine nucleotides, inhibits mTOR/S6K1 signaling, reduces GSH/GSSG, and induces Apoptosis. AGF347 exhibits anticancer activity against lung cancer, colon cancer, pancreatic cancer, and epithelial ovarian cancer cells.
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SHMT-IN-1
0 ImagesSHMT-IN-1 is a Plasmodium falciparum Serine Hydroxymethyltransferase (PfSHMT) inhibitor with an IC50 of 350 nM. SHMT-IN-1 can be used for the research of malaria.
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(-)SHIN2
0 ImagesCat. No.: HY-134978BPurity: 99.81%(-)SHIN2 is the isomer of (+)SHIN2 (HY-134978A). (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate (HY-14519) in vivo xenotransplantation models. (-)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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SHMT2-IN-1
0 ImagesCat. No.: HY-178432Purity: 99.84%SHMT2-IN-1 is a potent serine hydroxymethyltransferase 2 (SHMT2) inhibitor with an IC50 of 1.21 μM and a KD of 10.6 μM. SHMT2-IN-1 binds to the folate binding site of SHMT2. SHMT2-IN-1 also inhibits SHMT1 with an IC50 of 1.83 μM. SHMT2-IN-1 can inhibit cancer cells proliferation, migration and invasion. SHMT2-IN-1 can induce cells apoptosis and ROS production and cause G2/M phase arrest. SHMT2-IN-1 can be used for the research of cancer, such as esophageal cancer.
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HDAC11-IN-5
0 ImagesCat. No.: HY-182019Purity: 98.25%HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC50 of 0.021 μM. HDAC11-IN-5 increases fatty acylation levels of substrate SHMT2 in AML cells. HDAC11-IN-5 induces apoptosis, G1 phase cell cycle arrest, ferroptosis, ROS production and terminal myeloid differentiation in AML cells. HDAC11-IN-5 demonstrates anti-tumor potency in an MLL-AF9-induced mouse AML model. HDAC11-IN-5 can be used for the research of cancer, such as acute myeloid leukemia.
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Anticancer agent 310
0 ImagesCat. No.: HY-182284Anticancer agent 310 is an antitumor agent. Anticancer agent 310 releases nitric oxide to induce mitochondrial ROS burst, triggers mitochondrial dysfunction and activates the Bax/Bcl-2-Cyt c-Caspase-9/Caspase-3 apoptotic pathway. Anticancer agent 310 also reduces the levels of SHMT2 and MTHFD2, decreases the ratios of NADPH/NADP+ and GSH/GSSG, thereby disrupting redox homeostasis and exacerbating intracellular ROS accumulation. Anticancer agent 310 can be used in research related to gastric cancer.
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SHMT-IN-4
0 ImagesCat. No.: HY-162883CAS No.: 3014814-72-0SHMT-IN-4 (Compound 9ay) is a herbicide that targets and inhibits serine hydroxymethyltransferase (SHMT1) with an IC50 value of 193.8 g a.i./ha (active ingredient content per hectare). SHMT-IN-4 interferes with amino acid synthesis and metabolism in plants by binding to SHMT1, thereby inhibiting plant growth. Additionally, SHMT-IN-4 shows no significant toxicity to maize and honeybees.
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