2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis PI3K/Akt/mTOR NF-κB Immunology/Inflammation
  3. Antifolate SHMT Apoptosis mTOR Reactive Oxygen Species (ROS) Mitochondrial Metabolism
  4. AGF347

AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis, inhibits mTOR signaling, decreases GSH pools, and increases ROS. AGF347 inhibits proliferation of Cisplatin (HY-17394) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research.

For research use only. We do not sell to patients.

AGF347

AGF347 Chemical Structure

CAS No. : 2294820-23-6

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AGF347 Related Antibodies

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Description

AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis, inhibits mTOR signaling, decreases GSH pools, and increases ROS. AGF347 inhibits proliferation of Cisplatin (HY-17394) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research[1][2].

IC50 & Target[1][2]

mTOR

 

Human SHMT1

 

SHMT2

 

Molecular Weight

473.45

Formula

C22H24FN5O6
CAS No.
SMILES

FC(C=C1CCCCN2C3=C(NC(N)=NC3=O)C=C2)=C(C=C1)C(N[C@H](C(O)=O)CCC(O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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AGF347 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGF3472294820-23-6AGF 347AGF-347AntifolateSHMTApoptosismTORReactive Oxygen Species (ROS)Mitochondrial MetabolismSerine hydroxymethyltransferaseMammalian target of Rapamycinantifolatede novo purine biosynthesismTOR signalingCisplatinepithelial ovarian cancer cellsSKOV3 EOCInhibitorinhibitorinhibit

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