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SHMT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SHMT (6) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (5) Endocrinology (1)

Inhibitors & Agonists

Targets Recommended: SHMT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SHMT-IN-2	SHMT	Endocrinology Cancer
SHMT-IN-2 is a stereo specific inhibitor of human *SHMT1/2* with IC₅₀ values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas .

SHMT-IN-1	SHMT	Cancer
SHMT-IN-1 (compound (±)-46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT). SHMT-IN-1 has antitumor activity .

SHIN1 5+ Cited Publications RZ-2994	SHMT	Cancer
SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC₅₀s of 5 and 13 nM, respectively, in an in vitro assay.

SHMT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SHMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SHMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SHMT1 Human Pre-designed siRNA Set A SHMT1 Human Pre-designed siRNA Set A

SHMT2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SHMT2 Human Pre-designed siRNA Set A contains three designed siRNAs for SHMT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SHMT2 Human Pre-designed siRNA Set A SHMT2 Human Pre-designed siRNA Set A

(Rac)-SHIN2	SHMT	Others
(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor having 1,4-dihydropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase, respectively . (Rac)-SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

(-)SHIN2	SHMT	Cancer
(-)SHIN2 is the isomer of (+)SHIN2 (HY-134978A). (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate (HY-14519) in vivo xenotransplantation models . (-)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

(+)SHIN2	SHMT	Cancer
(+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, whose target can be traced with ¹³C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519) . (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Compare	Product Name	Species	Source

	SHMT2 Protein, Human SHMT2; Serine hydroxymethyltransferase; mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase	Human	E. coli
	The SHMT2 protein catalyzes the cleavage of serine to produce 5,10-methylenetetrahydrofolate for purine synthesis. It binds to mitochondrial DNA and participates in target protein deubiquitination via the BRISC complex. SHMT2 Protein, Human is the recombinant human-derived SHMT2 protein, expressed by E. coli , with tag free. The total length of SHMT2 Protein, Human is 476 a.a., .

	SHMT2 Protein, Human (His) SHMT2; Serine hydroxymethyltransferase; mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase	Human	E. coli
	The SHMT2 protein catalyzes the cleavage of serine to produce 5,10-methylenetetrahydrofolate for purine synthesis. It binds to mitochondrial DNA and participates in target protein deubiquitination via the BRISC complex. SHMT2 Protein, Human (His) is the recombinant human-derived SHMT2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SHMT2 Protein, Human (His) is 476 a.a., .


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