2294820-23-6
Chemical Structure
AGF347
- CAS No.: 2294820-23-6
- Formula:C22H24FN5O6
- Molecular Weight:473.45
InChIKey: XKLSPKTUYQAZHW-INIZCTEOSA-N
SMILES: FC(C=C1CCCCN2C3=C(NC(N)=NC3=O)C=C2)=C(C=C1)C(N[C@H](C(O)=O)CCC(O)=O)=O
Biological Activity: AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis, inhibits mTOR signaling, decreases GSH pools, and increases ROS. AGF347 inhibits proliferation of Cisplatin (HY-17394) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research[1][2].
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AGF347 | AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis, inhibits mTOR signaling, decreases GSH pools, and increases ROS. AGF347 inhibits proliferation of Cisplatin (HY-17394) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research. | |||||||||||||||||||||
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- [1]. Dekhne AS, et al. Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism. Mol Pharmacol. 2020 Jan;97(1):9-22. [Content Brief]
- [2]. Wallace-Povirk A, et al. Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer. Mol Cancer Ther. 2024 Jun 4;23(6):809-822. [Content Brief]
Keywords
