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(+)-SHIN1 (Synonyms: (+)-RZ-2994)

Cat. No.: HY-112066A
Handling Instructions

(+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1.

For research use only. We do not sell to patients.

(+)-SHIN1 Chemical Structure

(+)-SHIN1 Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 333 In-stock
Estimated Time of Arrival: December 31
1 mg USD 89 In-stock
Estimated Time of Arrival: December 31
5 mg USD 378 In-stock
Estimated Time of Arrival: December 31
10 mg USD 640 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1357 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2314 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4005 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (+)-SHIN1:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

(+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1[1].

In Vitro

(+)-SHIN1 ((+)-RZ-2994) is potent against cytosolic SHMT1 with an IC50 for blocking growth of less than 50 nM and 870 nM in SHMT2 deletion cells and HCT-116 cells, respectively[1].

Molecular Weight

400.47

Formula

C₂₄H₂₄N₄O₂

SMILES

OCC1=CC(C2=CC=CC=C2)=CC([[email protected]@]3(C(C(C)=NN4)=C4OC(N)=C3C#N)C(C)C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (249.71 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4971 mL 12.4853 mL 24.9707 mL
5 mM 0.4994 mL 2.4971 mL 4.9941 mL
10 mM 0.2497 mL 1.2485 mL 2.4971 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product name:
(+)-SHIN1
Cat. No.:
HY-112066A
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