dTAG-47-NEG
Based on 1 Customer Validation
dTAG-47-NEG is an analog of dTAG-47 that cannot bind and recruit cereblon (CRBN). dTAG-47-NEG can be used as a heterobifunctional negative control of dTAG-47.
(Pink: FKBP12 ligand (HY-114420); Blue: E3 ligase ligand; Black: linker (HY-42773)).
For research use only. We do not sell to patients.
- Purity: 97.8%
- Formula: C59H75N5O13
- Molecular Weight:1062.25
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
-
Cell Line:FKBP12[WT], FKBP12[F36V]
-
Concentration:100 nM
-
Incubation Time:24 hours
-
Result:Negative control for dTAG-47.
Chemical Information
-
Appearance Solid
-
Molecular Weight 1062.25
-
Formula C59H75N5O13
-
Color Light yellow to yellow
-
SMILES
O=C1N(C2C(NCCC2)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 106.22 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9414 mL | 4.7070 mL | 9.4140 mL | 23.5349 mL |
| 5 mM | 0.1883 mL | 0.9414 mL | 1.8828 mL | 4.7070 mL | |
| 10 mM | 0.0941 mL | 0.4707 mL | 0.9414 mL | 2.3535 mL | |
| 15 mM | 0.0628 mL | 0.3138 mL | 0.6276 mL | 1.5690 mL | |
| 20 mM | 0.0471 mL | 0.2353 mL | 0.4707 mL | 1.1767 mL | |
| 25 mM | 0.0377 mL | 0.1883 mL | 0.3766 mL | 0.9414 mL | |
| 30 mM | 0.0314 mL | 0.1569 mL | 0.3138 mL | 0.7845 mL | |
| 40 mM | 0.0235 mL | 0.1177 mL | 0.2353 mL | 0.5884 mL | |
| 50 mM | 0.0188 mL | 0.0941 mL | 0.1883 mL | 0.4707 mL | |
| 60 mM | 0.0157 mL | 0.0784 mL | 0.1569 mL | 0.3922 mL | |
| 80 mM | 0.0118 mL | 0.0588 mL | 0.1177 mL | 0.2942 mL |
Powered by Bioz