2. Membrane Transporter/Ion Channel
  3. GLUT
  4. SW157765

SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs.

For research use only. We do not sell to patients.

SW157765 Chemical Structure

SW157765 Chemical Structure

CAS No. : 332063-87-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 150 In-stock
25 mg USD 315 In-stock
50 mg USD 500 In-stock
100 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

SW157765 Related Antibodies

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Description

SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].

In Vitro

SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SW157765 Related Antibodies
Molecular Weight

331.32

Formula

C19H13N3O3
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C(NC1=CC=C(OC(C2=CC=NC=C2)=N3)C3=C1)/C=C/C4=CC=CO4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (75.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0182 mL 15.0911 mL 30.1823 mL
5 mM 0.6036 mL 3.0182 mL 6.0365 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0182 mL 15.0912 mL 30.1823 mL 75.4558 mL
5 mM 0.6036 mL 3.0182 mL 6.0365 mL 15.0912 mL
10 mM 0.3018 mL 1.5091 mL 3.0182 mL 7.5456 mL
15 mM 0.2012 mL 1.0061 mL 2.0122 mL 5.0304 mL
20 mM 0.1509 mL 0.7546 mL 1.5091 mL 3.7728 mL
25 mM 0.1207 mL 0.6036 mL 1.2073 mL 3.0182 mL
30 mM 0.1006 mL 0.5030 mL 1.0061 mL 2.5152 mL
40 mM 0.0755 mL 0.3773 mL 0.7546 mL 1.8864 mL
50 mM 0.0604 mL 0.3018 mL 0.6036 mL 1.5091 mL
60 mM 0.0503 mL 0.2515 mL 0.5030 mL 1.2576 mL
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SW157765 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SW157765332063-87-3SW 157765SW-157765GLUTGlucose transportersensitiveNSCLCcelllinesglucosedeprivationGLUT8depletionInhibitorinhibitorinhibit

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