1. Membrane Transporter/Ion Channel
  2. GLUT
  3. SW157765

SW157765 

Cat. No.: HY-139047
Handling Instructions

SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs.

For research use only. We do not sell to patients.

SW157765 Chemical Structure

SW157765 Chemical Structure

CAS No. : 332063-87-3

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Description

SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].

In Vitro

SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

331.32

Formula

C₁₉H₁₃N₃O₃

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
SW157765
Cat. No.:
HY-139047
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