KRAS inhibitor-31
Based on 1 publication(s) in Google Scholar
KRAS inhibitor-31 (compound 33) is a KRAS inhibitor, with KD (SPR) values of 0.019 nM, 0.019 nM and 0.096 nM for KRas G12D, KRas G12C and KRas G12V, respectively.
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- Pureté : 99.36%
- CAS No.: 2920695-77-6
- Formule: C33H30F3N5O4
- Masse moléculaire:617.62
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) KRAS inhibitor-31
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Activité biologique
Description
IC50 & Target
[1]|
KRas G12D 0.019 nM (Kd) |
KRas G12C 0.019 nM (Kd) |
KRas G12V 0.096 nM (Kd) |
In Vitro
KRAS inhibitor-31 (compound 33) exhibits IC50 values of 1.1 nM, 3.9 nM and 6.6 nM in Panc08.13, H358 and SW620 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2920695-77-6
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Appearance Solid
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Masse moléculaire 617.62
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Formule C33H30F3N5O4
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Color White to off-white
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SMILES
FC1=C(C2=CC(O)=CC3=C2C(C#C)=C(F)C=C3)N=C4OC[C@@](COCCC5)([H])N5C6=C4C1=NC(OC[C@@]78N(CCC8)C[C@@H](C7)F)=N6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (161.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6191 mL | 8.0956 mL | 16.1912 mL | 40.4780 mL |
| 5 mM | 0.3238 mL | 1.6191 mL | 3.2382 mL | 8.0956 mL | |
| 10 mM | 0.1619 mL | 0.8096 mL | 1.6191 mL | 4.0478 mL | |
| 15 mM | 0.1079 mL | 0.5397 mL | 1.0794 mL | 2.6985 mL | |
| 20 mM | 0.0810 mL | 0.4048 mL | 0.8096 mL | 2.0239 mL | |
| 25 mM | 0.0648 mL | 0.3238 mL | 0.6476 mL | 1.6191 mL | |
| 30 mM | 0.0540 mL | 0.2699 mL | 0.5397 mL | 1.3493 mL | |
| 40 mM | 0.0405 mL | 0.2024 mL | 0.4048 mL | 1.0119 mL | |
| 50 mM | 0.0324 mL | 0.1619 mL | 0.3238 mL | 0.8096 mL | |
| 60 mM | 0.0270 mL | 0.1349 mL | 0.2699 mL | 0.6746 mL | |
| 80 mM | 0.0202 mL | 0.1012 mL | 0.2024 mL | 0.5060 mL | |
| 100 mM | 0.0162 mL | 0.0810 mL | 0.1619 mL | 0.4048 mL |
KRAS inhibitor-31 Related Classifications
HY-159652 Related Classifications
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