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Cat. No.: HY-146533

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KRAS inhibitor-12

KRAS inhibitor-12 is a KRAS and KRAS^G12C inhibitor that inhibits KRAS^G12C-coupled nucleotide exchange (IC₅₀ = 0.537 µM). KRAS inhibitor-12 can be used for research on pancreatic cancer, colorectal cancer, and lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2230874-00-5
Formula: C₁₉H₁₆Cl₂FN₅OS
Molecular Weight:452.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

KRAS inhibitor-12 Chemical Structure

CAS No.: 2230874-00-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

KRas G12C

0.537 μM (IC₅₀)

All Ras Isoforms :

In Vitro

Anti-cancer

KRAS inhibitor-12 (compound 6-1) is a covalent KRAS^G12C inhibitor containing a piperazine-acrylamide scaffold; it inhibits KRAS^G12C-coupled nucleotide exchange (IC₅₀ = 0.537 µM) and suppresses p-ERK signaling in MIA PaCa-2 pancreatic cancer cells (IC₅₀ = 1.3 µM) and A549 non-small cell lung cancer cells (IC₅₀ = 3.7 µM)^[1]_.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2230874-00-5
Molecular Weight 452.33
Formula C₁₉H₁₆Cl₂FN₅OS
SMILES

O=C(N1CCN(CC1)C2=C3C=C(Cl)C(C4=C(Cl)C=CC(N)=N4)=C(F)C3=NS2)C=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lanman B A, et al. Kras g12c inhibitors and methods of using the same. WO2018119183A2. WIPO. 2018‑06‑28.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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