2230874-00-5
2230874-00-5
Chemical Structure
KRAS inhibitor-12
- CAS No.: 2230874-00-5
- Formula:C19H16Cl2FN5OS
- Molecular Weight:452.33
IUPAC Name: 1-(4-(6-(6-amino-3-chloropyridin-2-yl)-5-chloro-7-fluorobenzo[c]isothiazol-3-yl)piperazin-1-yl)prop-2-en-1-one
InChIKey: MOIGORLHBXDEMI-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC1)C2=C3C=C(Cl)C(C4=C(Cl)C=CC(N)=N4)=C(F)C3=NS2)C=C
Biological Activity: KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
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KRAS inhibitor-12 | KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers. | |||||||||||||||||||||
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