KRAS inhibitor-17
KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers.
For research use only. We do not sell to patients.
- CAS No.: 2230873-65-9
- Formula: C21H18Cl2FN3O2S
- Molecular Weight:466.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRas G12C 3.37 μM (IC50) |
Chemical Information
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CAS No. 2230873-65-9
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Molecular Weight 466.36
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Formula C21H18Cl2FN3O2S
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SMILES
C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(OC)=CC=C4Cl)=C(C3=NS2)F)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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