2230873-65-9
Chemical Structure
KRAS inhibitor-17
- CAS No.: 2230873-65-9
- Formula:C21H18Cl2FN3O2S
- Molecular Weight:466.36
IUPAC Name: 1-(4-(5-chloro-6-(2-chloro-5-methoxyphenyl)-7-fluorobenzo[c]isothiazol-3-yl)piperazin-1-yl)prop-2-en-1-one
InChIKey: UPTMOORQEKJHRA-UHFFFAOYSA-N
SMILES: C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(OC)=CC=C4Cl)=C(C3=NS2)F)Cl)=O
Biological Activity: KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
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KRAS inhibitor-17 | KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers. | |||||||||||||||||||||
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Keywords
