KRAS inhibitor-37
KRAS inhibitor-37 (compound 2) is a potent KRAS inhibitor with KDs of 0.004 nM, 0.041 nM, 0.019 nM and 0.144 nM for KRAS wild type, KRAS G12D, KRAS G12C and KRAS G12V by SPR binding assay, respectively. KRAS inhibitor-37 inhibits cell proliferation with IC50s of <2 nM-14 nM for H358, SW620, PANC08.13 cells, respectively. KRAS inhibitor-37 has the potential for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3058573-95-5
- Formula: C32H33ClFN7O3
- Molecular Weight:618.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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K-Ras WT 0.004 nM (Kd) |
KRas G12D 0.041 nM (Kd) |
KRas G12C 0.019 nM (Kd) |
KRas G12V 0.144 nM (Kd) |
Chemical Information
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CAS No. 3058573-95-5
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Molecular Weight 618.10
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Formula C32H33ClFN7O3
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SMILES
C=C1CN2CCC[C@]2(C1)COC3=NC4=C5C(OC[C@@H]6COCCCN6C5=N3)=NC(C7=C8C=NNC8=CC(Cl)=C7C9CC9)=C4F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS inhibitor-37 Related Classifications
HY-169311 Related Classifications
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