KRAS inhibitor-3
Based on 1 publication(s) in Google Scholar
KRAS inhibitor-3 is an inhibitor of KRAS inhibitor. KRAS inhibitor-3 binds to WT and oncogenic KRAS mutants with high affinity (KD: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, 0.74 μM for KRAS Q61H). KRAS inhibitor-3 also disrupts interaction of KRAS with Raf.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 900897-56-5
- Formula: C25H27N5O
- Molecular Weight:413.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) KRAS inhibitor-3
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Biological Activity
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K-Ras WT 0.28 μM (EC50) |
KRAS(G12C) 0.63 μM (EC50) |
KRas G12D 0.37 μM (EC50) |
KRas Q61H 0.74 μM (EC50) |
KRAS inhibitor-3 (Compound 11, 0-1 μM, 72 h) inhibits growth of KRAS-expressing lung cancer cells[1].
KRAS inhibitor-3 (0-5 μM) decreases the p-ERK levels in BHK cells stably expressing KRASG12D[1].
KRAS inhibitor-3 (1 μM, 2 h) disrupts interaction of KRAS with Raf[1].
KRAS inhibitor-3 (0-5 μM) decreases both p-ERK and p-cRaf levels in BHK cells expressing KRASG12D and KRASG12V[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BHK cells stably expressing KRASG12D
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Concentration:0.01, 0.1, 0.5 1, 5 μM
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Incubation Time:
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Result:Decreased the p-ERK levels at >1μM.
Chemical Information
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CAS No. 900897-56-5
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Appearance Solid
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Molecular Weight 413.51
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Formula C25H27N5O
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Color Light yellow to yellow
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SMILES
OCCN1CCN(CC1)C2=CC(C3=CC=CC=C3)=NC4=C(C(C)=NN42)C5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 50 mg/mL (120.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4183 mL | 12.0916 mL | 24.1832 mL | 60.4580 mL |
| 5 mM | 0.4837 mL | 2.4183 mL | 4.8366 mL | 12.0916 mL | |
| 10 mM | 0.2418 mL | 1.2092 mL | 2.4183 mL | 6.0458 mL | |
| 15 mM | 0.1612 mL | 0.8061 mL | 1.6122 mL | 4.0305 mL | |
| 20 mM | 0.1209 mL | 0.6046 mL | 1.2092 mL | 3.0229 mL | |
| 25 mM | 0.0967 mL | 0.4837 mL | 0.9673 mL | 2.4183 mL | |
| 30 mM | 0.0806 mL | 0.4031 mL | 0.8061 mL | 2.0153 mL | |
| 40 mM | 0.0605 mL | 0.3023 mL | 0.6046 mL | 1.5115 mL | |
| 50 mM | 0.0484 mL | 0.2418 mL | 0.4837 mL | 1.2092 mL | |
| 60 mM | 0.0403 mL | 0.2015 mL | 0.4031 mL | 1.0076 mL | |
| 80 mM | 0.0302 mL | 0.1511 mL | 0.3023 mL | 0.7557 mL | |
| 100 mM | 0.0242 mL | 0.1209 mL | 0.2418 mL | 0.6046 mL |
KRAS inhibitor-3 Related Classifications
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