900897-56-5
900897-56-5
Chemical Structure
KRAS inhibitor-3
- CAS No.: 900897-56-5
- Formula:C25H27N5O
- Molecular Weight:413.51
IUPAC Name: 2-(4-(2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)ethan-1-ol
InChIKey: MTHOJIJARWDIJS-UHFFFAOYSA-N
SMILES: OCCN1CCN(CC1)C2=CC(C3=CC=CC=C3)=NC4=C(C(C)=NN42)C5=CC=CC=C5
Biological Activity: KRAS inhibitor-3 is an inhibitor of KRAS inhibitor. KRAS inhibitor-3 binds to WT and oncogenic KRAS mutants with high affinity (KD: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, 0.74 μM for KRAS Q61H). KRAS inhibitor-3 also disrupts interaction of KRAS with Raf[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KRAS inhibitor-3 | 99.87% | KRAS inhibitor-3 is an inhibitor of KRAS inhibitor. KRAS inhibitor-3 binds to WT and oncogenic KRAS mutants with high affinity (KD: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, 0.74 μM for KRAS Q61H). KRAS inhibitor-3 also disrupts interaction of KRAS with Raf. | ||||||||||||||||||||
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References
Keywords
