1. MAPK/ERK Pathway
  2. Ribosomal S6 Kinase (RSK)
  3. LJI308

LJI308 

Cat. No.: HY-19713 Purity: 99.82%
Handling Instructions

LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation.

For research use only. We do not sell to patients.

LJI308 Chemical Structure

LJI308 Chemical Structure

CAS No. : 1627709-94-7

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Solution
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 198 In-stock
Estimated Time of Arrival: December 31
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5 mg USD 180 In-stock
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10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
25 mg USD 672 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1188 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1980 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    LJI308 purchased from MCE. Usage Cited in: Oncotarget. 2017 Jun 6;8(23):37633-37645.

    Western blot analysis of Plk1 and RSK1 activation in CSC-like cells after treatment with LJI308 for 72 hours. α-Tubulin served as a loading control (bottom panel).
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    Description

    LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation[1][2].

    In Vitro

    LJI308 inhibits S6K1 with an IC50 of 0.8 μM[1].
    LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells[2].
    LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[3]

    Cell Line: HTRY-LT cell lines
    Concentration: 1-10 μM
    Incubation Time: 96 hours
    Result: Decreased cell viability by up to 90%.
    Molecular Weight

    368.38

    Formula

    C₂₁H₁₈F₂N₂O₂

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (67.86 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7146 mL 13.5729 mL 27.1459 mL
    5 mM 0.5429 mL 2.7146 mL 5.4292 mL
    10 mM 0.2715 mL 1.3573 mL 2.7146 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.79 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Product Name:
    LJI308
    Cat. No.:
    HY-19713
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