1627709-94-7
1627709-94-7
Chemical Structure
LJI308
- CAS No.: 1627709-94-7
- Formula:C21H18F2N2O2
- Molecular Weight:368.38
IUPAC Name: 2,6-difluoro-4-(4-(4-morpholinophenyl)pyridin-3-yl)phenol
InChIKey: YUYJEQHNWKQNBT-UHFFFAOYSA-N
SMILES: OC1=C(C=C(C=C1F)C2=C(C=CN=C2)C3=CC=C(C=C3)N4CCOCC4)F
Biological Activity: LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LJI308 | 99.07% | LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation. | ||||||||||||||||||||
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References
- [1]. Aronchik I, et al. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol Cancer Res. 2014 May;12(5):803-12. [Content Brief]
- [2]. Lettau K, et al. Simultaneous Targeting of RSK and AKT Efficiently Inhibits YB-1-Mediated Repair of Ionizing Radiation-Induced DNA Double-Strand Breaks in Breast Cancer Cells. Int J Radiat Oncol Biol Phys. 2021;109(2):567-580. [Content Brief]
