KRAS G12D inhibitor 26
Based on 1 Customer Validation
KRAS G12D inhibitor 26 is a modulator of Kras, targeting Kras(G12D) with an IC50 ≤ 100 nM.
For research use only. We do not sell to patients.
- Purity: 98.39%
- CAS No.: 2972625-49-1
- Formula: C35H44ClFN8O2
- Molecular Weight:663.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Kras(G12D)[1]
Chemical Information
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CAS No. 2972625-49-1
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Appearance Solid
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Molecular Weight 663.23
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Formula C35H44ClFN8O2
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Color Light yellow to yellow
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SMILES
CN1[C@@]2(CC3=NC(OC[C@@]45N(CCC5)C[C@@H](C4)F)=NC(N6CC7=C(Cl)C(C(N(C)C)=O)=NN7CCC6)=C3C1)C8=CC=CC=C8CCC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (150.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5078 mL | 7.5389 mL | 15.0777 mL | 37.6943 mL |
| 5 mM | 0.3016 mL | 1.5078 mL | 3.0155 mL | 7.5389 mL | |
| 10 mM | 0.1508 mL | 0.7539 mL | 1.5078 mL | 3.7694 mL | |
| 15 mM | 0.1005 mL | 0.5026 mL | 1.0052 mL | 2.5130 mL | |
| 20 mM | 0.0754 mL | 0.3769 mL | 0.7539 mL | 1.8847 mL | |
| 25 mM | 0.0603 mL | 0.3016 mL | 0.6031 mL | 1.5078 mL | |
| 30 mM | 0.0503 mL | 0.2513 mL | 0.5026 mL | 1.2565 mL | |
| 40 mM | 0.0377 mL | 0.1885 mL | 0.3769 mL | 0.9424 mL | |
| 50 mM | 0.0302 mL | 0.1508 mL | 0.3016 mL | 0.7539 mL | |
| 60 mM | 0.0251 mL | 0.1256 mL | 0.2513 mL | 0.6282 mL | |
| 80 mM | 0.0188 mL | 0.0942 mL | 0.1885 mL | 0.4712 mL | |
| 100 mM | 0.0151 mL | 0.0754 mL | 0.1508 mL | 0.3769 mL |
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