PAQR3 - progestin and adipoQ receptor family member 3 Gene

Also Known as RKTG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 152559

Summary

This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Broad expression in testis (RPKM 20.7), brain (RPKM 8.5) and 24 other tissues.

PAQR3 Products (1)

mRNA Protein Name
NG_053104.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17724343 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
17724343 GOA
acts upstream of or within negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
17724343 GOA
acts upstream of or within negative regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
17724343 GOA
acts upstream of or within negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
17724343 GOA
acts upstream of or within protein localization to Golgi apparatus IPI
IPI: Inferred from physical interaction
17724343 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17724343 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAQR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAQR3 Q6TCH7 RAF1 Homo sapiens P04049
Anti Tag CoIP
17724343
Intra
PAQR3 Q6TCH7 RAF1 Homo sapiens P04049
Anti Bait CoIP
17724343
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16424 PAQR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21680 Paqr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28198 Paqr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown