CDC25A - cell division cycle 25A Gene

Also Known as CDC25A2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 993

About CDC25A

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,157,146-48,188,417 (from NCBI)

This gene has 5 transcripts (splice variants), 156 orthologues and 2 paralogues. Broad expression in testis (RPKM 7.4), bone marrow (RPKM 4.6) and 15 other tissues.

Summary

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CDC25A Products (2)

mRNA	Protein	Name
NM_001789.3	NP_001780.2	M-phase inducer phosphatase 1 isoform a
NM_201567.2	NP_963861.1	M-phase inducer phosphatase 1 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	20360007	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7644510	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21376736	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	20360007	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	22843495	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	20360007	GOA
involved in cellular response to UV	IDA IDA: Inferred from direct assay	19966869	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	20360007	GOA
involved in response to radiation	IDA IDA: Inferred from direct assay	21376736	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC25A Protein Structure

M-inducer_phosp

Rhodanese

0
100
200
300
400
500
524 a.a.

Protein Preferred Names	Protein Names
M-phase inducer phosphatase 1	CDC25 homolog A

CDC25A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC25A	P30304	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183
Intra	CDC25A	P30304	YWHAZ	Homo sapiens	P63104	Far-WB	15161933
Intra	CDC25A	P30304	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	CDC25A	P30304	YWHAE	Homo sapiens	P62258	Anti Bait CoIP	14559997
Intra	CDC25A	P30304	YWHAB	Homo sapiens	P31946	BioID	28330616
Intra	CDC25A	P30304	YWHAB	Homo sapiens	P31946	Pull Down	28330616
Intra	CDC25A	P30304	YWHAB	Homo sapiens	P31946	Anti Bait CoIP	7644510
Intra	CDC25A	P30304	YWHAB	Homo sapiens	P31946	Y2H	7644510
Intra	CDC25A	P30304	YWHAQ	Homo sapiens	P27348	BioID	28330616
Intra	CDC25A	P30304	YWHAQ	Homo sapiens	P27348	Pull Down	28330616
Intra	CDC25A	P30304	RAF1	Homo sapiens	P04049	Anti Bait CoIP	7644510

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC25A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810857	Phospho-CDC25A (Ser124) Antibody	WB, ICC/IF	Human, Mouse, Rat
HY-P811153	Phospho-CDC25A (Ser82) Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Purity	Phase
HY-18174	Prexasertib	99.64%	Phase 2
HY-18174A	Prexasertib dihydrochloride	99.73%	Phase 2
HY-18174E	Prexasertib dimesylate	98.90%	Phase 2
HY-18174B	Prexasertib Mesylate Hydrate	/	Phase 2
HY-18174C	Prexasertib mesylate	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108543	NSC 95397		99.0%	Unkown
HY-100034	NSC 663284	Inhibitor	99.29%	Unkown
HY-132578	M5N36	Inhibitor	98.00%	Unkown
HY-112776A	BN82002 hydrochloride	Inhibitor	99.36%	Unkown
HY-121065	BN-82685	Inhibitor	99.05%	Unkown
HY-128769	M2N12	Inhibitor	98.19%	Unkown
HY-N7045	Isosilybin B		99.32%	Unkown
HY-155816	PROTAC NSD3 degrader-1		99.40%	Unkown
HY-W024644	Hydroxyethylthio Vitamine K3		≥97.0%	Unkown
HY-112776	BN82002	Inhibitor	/	Unkown
HY-118529	JUN-1111	Inhibitor	98.57%	Unkown
HY-RS02291	CDC25A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-178295	VHR-IN-5	Inhibitor	/	Unkown
HY-178296	VHR-IN-6	Inhibitor	/	Unkown
HY-178297	VHR-IN-7	Inhibitor	/	Unkown
HY-178301	VHR-IN-9	Inhibitor	/	Unkown
HY-181011	PROTAC Cdc25 degrader-1		/	Unkown
HY-184446	CDC25A/NF-κB-IN-1		/	Unkown
HY-28086	CDC25-IN-2	Inhibitor	/	Unkown
HY-P4979	Cdc25A (80-93) (human)		/	Unkown
HY-18174H	Prexasertib lactate		/	Unkown
HY-RS17278	Cdc25a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23732	Cdc25a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDC25A	RGD	RGD:621498
Canis familiaris	CDC25A	VGNC	VGNC:38989
Mus musculus	CDC25A	MGD	MGI:103198
Bos taurus	CDC25A	VGNC	VGNC:27062
Felis catus	CDC25A	VGNC	VGNC:60649
Macaca mulatta	CDC25A	VGNC	VGNC:70794
Others	CDC25A	NCBI