VHR-IN-7
VHR-IN-7 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 71 nM. VHR-IN-7 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.47 μM), CD45 (IC50 = 0.3 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 0.59 μM), and HePTP (IC50 = 1.2 μM). VHR-IN-7 inhibits the proliferation of HeLa cells. VHR-IN-7 can be used for the research of cervical cancer.
For research use only. We do not sell to patients.
- CAS No.: 1146616-17-2
- Formula: C28H22ClN3O5S3
- Molecular Weight:612.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
VHR-IN-7 (Compound SA2) (20 μM, 24 h) inhibits the proliferation of HeLa cells and has no significant toxicity to the survival and proliferation of normal human keratinocytes (NK cells)[1].
VHR-IN-7 (20 μM, 24 h) does not induce HeLa and CasKi cells apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa and CasKi cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Did not induce HeLa and CasKi cells apoptosis.
Chemical Information
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CAS No. 1146616-17-2
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Molecular Weight 612.14
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Formula C28H22ClN3O5S3
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SMILES
ClC(C=CC=C1)=C1COC(C=C2)=CC=C2C3=NN(C4=CC=CC=C4)C=C3/C=C5C(N(C(S/5)=S)CCS(=O)(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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