VHR-IN-7
VHR-IN-7 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 71 nM. VHR-IN-7 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.47 μM), CD45 (IC50 = 0.3 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 0.59 μM), and HePTP (IC50 = 1.2 μM). VHR-IN-7 inhibits the proliferation of HeLa cells. VHR-IN-7 can be used for the research of cervical cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1146616-17-2
- 分子式: C28H22ClN3O5S3
- 分子量:612.14
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
VHR-IN-7 (Compound SA2) (20 μM, 24 h) inhibits the proliferation of HeLa cells and has no significant toxicity to the survival and proliferation of normal human keratinocytes (NK cells)[1].
VHR-IN-7 (20 μM, 24 h) does not induce HeLa and CasKi cells apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa and CasKi cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Did not induce HeLa and CasKi cells apoptosis.
化学情報
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CAS 番号 1146616-17-2
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分子量 612.14
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分子式 C28H22ClN3O5S3
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SMILES
ClC(C=CC=C1)=C1COC(C=C2)=CC=C2C3=NN(C4=CC=CC=C4)C=C3/C=C5C(N(C(S/5)=S)CCS(=O)(O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
VHR-IN-7 関連分類
HY-178297 関連分類
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