2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. VHR-IN-7

VHR-IN-7 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 71 nM. VHR-IN-7 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.47 μM), CD45 (IC50 = 0.3 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 0.59 μM), and HePTP (IC50 = 1.2 μM). VHR-IN-7 inhibits the proliferation of HeLa cells. VHR-IN-7 can be used for the research of cervical cancer.

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VHR-IN-7

VHR-IN-7 Chemical Structure

CAS No. : 1146616-17-2

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VHR-IN-7 Related Antibodies

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Description

VHR-IN-7 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 71 nM. VHR-IN-7 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.47 μM), CD45 (IC50 = 0.3 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 0.59 μM), and HePTP (IC50 = 1.2 μM). VHR-IN-7 inhibits the proliferation of HeLa cells. VHR-IN-7 can be used for the research of cervical cancer[1].

In Vitro

VHR-IN-7 (Compound SA2) (20 μM, 24 h) inhibits the proliferation of HeLa cells and has no significant toxicity to the survival and proliferation of normal human keratinocytes (NK cells)[1].
VHR-IN-7 (20 μM, 24 h) does not induce HeLa and CasKi cells apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VHR-IN-7 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HeLa and CasKi cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Did not induce HeLa and CasKi cells apoptosis.
Molecular Weight

612.14

Formula

C28H22ClN3O5S3
CAS No.
SMILES

ClC(C=CC=C1)=C1COC(C=C2)=CC=C2C3=NN(C4=CC=CC=C4)C=C3/C=C5C(N(C(S/5)=S)CCS(=O)(O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VHR-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VHR-IN-71146616-17-2PhosphataseVHR phosphatasemultidentate inhibitorscervical cancerstructure-based drug designselectivityInhibitorinhibitorinhibit

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