1146616-17-2
Chemical Structure
VHR-IN-7
- CAS No.: 1146616-17-2
- Formula:C28H22ClN3O5S3
- Molecular Weight:612.14
InChIKey: WILPFKVTYXJQQV-XYGWBWBKSA-N
SMILES: ClC(C=CC=C1)=C1COC(C=C2)=CC=C2C3=NN(C4=CC=CC=C4)C=C3/C=C5C(N(C(S/5)=S)CCS(=O)(O)=O)=O
Biological Activity: VHR-IN-7 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 71 nM. VHR-IN-7 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.47 μM), CD45 (IC50 = 0.3 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 0.59 μM), and HePTP (IC50 = 1.2 μM). VHR-IN-7 inhibits the proliferation of HeLa cells. VHR-IN-7 can be used for the research of cervical cancer[1].
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VHR-IN-7 | VHR-IN-7 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 71 nM. VHR-IN-7 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.47 μM), CD45 (IC50 = 0.3 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 0.59 μM), and HePTP (IC50 = 1.2 μM). VHR-IN-7 inhibits the proliferation of HeLa cells. VHR-IN-7 can be used for the research of cervical cancer. | |||||||||||||||||||||
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Keywords
