VHR-IN-5
VHR-IN-5 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 78 nM. VHR-IN-5 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.78 μM), CD45 (IC50 = 0.61 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 1.8 μM), and HePTP (IC50 = 1.5 μM). VHR-IN-5 inhibits the proliferation of HeLa cells. VHR-IN-5 can be used for the research of cervical cancer.
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- CAS No.: 956442-05-0
- 화학식: C28H23N3O5S3
- 분자량:577.69
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
VHR-IN-5 (Compound SA4) (20 μM, 24 h) inhibits the proliferation of HeLa cells and has no significant toxicity to the survival and proliferation of normal human keratinocytes (NK cells)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 956442-05-0
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분자량 577.69
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화학식 C28H23N3O5S3
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SMILES
O=C(N(C(S/1)=S)CCS(=O)(O)=O)C1=C\C2=CN(C3=CC=CC=C3)N=C2C4=CC=C(C=C4)OCC5=CC=CC=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VHR-IN-5 Related Classifications
HY-178295 Related Classifications
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