VHR-IN-6
VHR-IN-6 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 74 nM. VHR-IN-6 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.52 μM), CD45 (IC50 = 0.50 μM), Cdc25A (IC50 = 2.8 μM), PTP1B (IC50 = 0.42 μM), and HePTP (IC50 = 0.87 μM). VHR-IN-6 inhibits the proliferation of HeLa cells. VHR-IN-6 can be used for the research of cervical cancer.
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- No. CAS: 1146616-16-1
- Fòrmula: C28H22FN3O5S3
- Peso molecular:595.68
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
VHR-IN-6 (Compound SA3) (20 μM, 24 h) inhibits the proliferation of HeLa cells and has no significant toxicity to the survival and proliferation of normal human keratinocytes (NK cells)[1].
VHR-IN-6 (20 μM, 24 h) does not induce HeLa and CasKi cells apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa and CasKi cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Did not induce HeLa and CasKi cells apoptosis.
Chemical Information
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No. CAS 1146616-16-1
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Peso molecular 595.68
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Fòrmula C28H22FN3O5S3
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SMILES
FC(C=CC=C1)=C1COC(C=C2)=CC=C2C3=NN(C4=CC=CC=C4)C=C3/C=C5C(N(C(S/5)=S)CCS(=O)(O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VHR-IN-6 Related Classifications
HY-178296 Related Classifications
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