KSR1 - kinase suppressor of ras 1 Gene

Also Known as KSR; RSU2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8844

About KSR1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:27,456,448-27,626,435 (from NCBI)

This gene has 20 transcripts (splice variants), 272 orthologues and 23 paralogues. Ubiquitous expression in placenta (RPKM 8.2), endometrium (RPKM 5.8) and 23 other tissues.

Summary

Enables 14-3-3 protein binding activity; ATP binding activity; and protein C-terminus binding activity. Involved in positive regulation of MAPK cascade. Located in endoplasmic reticulum and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

KSR1 Products (5)

mRNA Protein Name
NM_001367810.1 NP_001354739.1 kinase suppressor of Ras 1 isoform 2
NM_001394583.1 NP_001381512.1 kinase suppressor of Ras 1 isoform 3
NM_001394584.1 NP_001381513.1 kinase suppressor of Ras 1 isoform 4
NM_001394585.1 NP_001381514.1 kinase suppressor of Ras 1 isoform 5
NM_014238.2 NP_055053.1 kinase suppressor of Ras 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
29433126 GOA
enables ATP binding IDA
IDA: Inferred from direct assay
29433126 GOA
enables protein binding IDA
IDA: Inferred from direct assay
22572157 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11909642 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
29433126 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22572157 GOA
located in membrane IDA
IDA: Inferred from direct assay
22572157 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
22572157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KSR1 Protein Structure

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (477 - 739)

  • 0
  • 200
  • 400
  • 600
  • 762 a.a.
Protein Preferred Names Protein Names

kinase suppressor of Ras 1

KSR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KSR1 Q8IVT5 MAP2K2 Homo sapiens P36507
Y2H
11909642
Intra
KSR1 Q8IVT5 MAP2K2 Homo sapiens P36507
Anti Tag CoIP
27086506
Cross: Cross-species interaction Intra: Intraspecies interaction

KSR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81646 KSR1 Antibody (YA1391) WB, IHC-P, ICC/IF, FC Human, Mouse

Related Diseases

Diseases Alias
Breast Adenocarcinoma

  • Mammary Adenocarcinoma

  • Adenocarcinoma Of Breast
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Rasopathy

  • Ras/Mitogen-Activated Protein Kinase Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07475 KSR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19611 Ksr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26106 Ksr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KSR1 VGNC VGNC:74221
Bos taurus KSR1 VGNC VGNC:30754
Felis catus KSR1 VGNC VGNC:97479
Mus musculus KSR1 MGD MGI:105051
Rattus norvegicus KSR1 RGD RGD:1308105
Canis familiaris KSR1 VGNC VGNC:42547
Others KSR1 NCBI