MLF2 - myeloid leukemia factor 2 Gene

Also Known as NTN4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8079

About MLF2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,747,996-6,753,141 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 67.7), prostate (RPKM 51.7) and 25 other tissues.

Summary

Predicted to be involved in regulation of transcription, DNA-templated. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MLF2 Products (3)

mRNA Protein Name
NM_001382225.1 NP_001369154.1 myeloid leukemia factor 2
NM_001382226.1 NP_001369155.1 myeloid leukemia factor 2
NM_005439.3 NP_005430.1 myeloid leukemia factor 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23414517 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLF2 Protein Structure

Mlf1IP

Mlf1IP: Myelodysplasia-myeloid leukemia factor 1-interacting protein (26 - 200)

  • 0
  • 100
  • 200
  • 248 a.a.
Protein Preferred Names Protein Names

myeloid leukemia factor 2

  • myelodysplasia-myeloid leukemia factor 2

MLF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MLF2 Q15773 DNAJB6 Homo sapiens O75190
Y2H Fragment Pooling
23414517
Intra
MLF2 Q15773 DNAJB6 Homo sapiens O75190
Anti Tag CoIP
25036637
Intra
MLF2 Q15773 BAG2 Homo sapiens O95816
Lumier
25036637
Intra
MLF2 Q15773 BAG2 Homo sapiens O95816
Anti Tag CoIP
25036637
Intra
MLF2 Q15773 BAG2 Homo sapiens O95816
Anti Bait CoIP
17353931
Intra
MLF2 Q15773 STUB1 Homo sapiens Q9UNE7
Lumier
25036637
Intra
MLF2 Q15773 RAF1 Homo sapiens P04049
Lumier
25036637
Intra
MLF2 Q15773 MLF1 Homo sapiens P58340
Lumier
25036637
Intra
MLF2 Q15773 HSPB8 Homo sapiens Q9UJY1
Y2H Fragment Pooling
23414517
Intra
MLF2 Q15773 BAG3 Homo sapiens O95817
Anti Tag CoIP
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myeloid Leukemia

  • Myeloid Leukaemia

  • Leukaemia Myelogenous

  • Leukemia Myelogenous

  • Myeloid Granulocytic Leukaemia

  • Myeloid Granulocytic Leukemia

  • Non-Lymphocytic Leukemia

  • Leukemia, Myeloid

  • Granulocytic Leukaemia

  • Myelogenous Leukaemia

  • Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Fatal Infantile Hypertonic Myofibrillar Myopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08488 MLF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MLF2 RGD RGD:1306294
Mus musculus MLF2 MGD MGI:1353554
Others MLF2 NCBI