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CDC25B - cell division cycle 25B Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 994

About CDC25B

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,786,951-3,806,115 (from NCBI)

This gene has 9 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 21.4), appendix (RPKM 15.3) and 24 other tissues.

Summary

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into Mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

CDC25B Products (10)

mRNA	Protein	Name
NM_001287516.2	NP_001274445.1	M-phase inducer phosphatase 2 isoform 4
NM_001287517.2	NP_001274446.1	M-phase inducer phosphatase 2 isoform 5
NM_001287518.2	NP_001274447.1	M-phase inducer phosphatase 2 isoform 6
NM_001287519.2	NP_001274448.1	M-phase inducer phosphatase 2 isoform 7
NM_001287520.2	NP_001274449.1	M-phase inducer phosphatase 2 isoform 7
NM_001287522.2	NP_001274451.1	M-phase inducer phosphatase 2 isoform 8
NM_001287524.2	NP_001274453.1	M-phase inducer phosphatase 2 isoform 9
NM_004358.5	NP_004349.1	M-phase inducer phosphatase 2 isoform 2
NM_021872.4	NP_068658.1	M-phase inducer phosphatase 2 isoform 3
NM_021873.4	NP_068659.1	M-phase inducer phosphatase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	20360007	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7644510	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12400006	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	20360007	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	17332740	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17332740	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17332740	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	15908796	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	15908796	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC25B Protein Structure

M-inducer_phosp

Rhodanese

0
100
200
300
400
500
580 a.a.

Protein Preferred Names	Protein Names
M-phase inducer phosphatase 2	CDC25 homolog B

CDC25B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	CoIP	16672277
Intra	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	Y2H	10713667
Intra	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	Affinity Chrom	10713667
Intra	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
Intra	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	26496610
Intra	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Y2H	10713667
Intra	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Affinity Chrom	10713667
Intra	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
Intra	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Pull Down	12766774
Intra	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	28514442
Intra	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Pull Down	12764136
Intra	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	26496610
Intra	CDC25B	P30305	PSME3	Homo sapiens	P61289	Validated Y2H	32296183
Intra	CDC25B	P30305	PSME3	Homo sapiens	P61289	Y2H Array	32296183
Intra	CDC25B	P30305	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	32296183
Intra	CDC25B	P30305	YWHAE	Homo sapiens	P62258	Affinity Chrom	12871587
Intra	CDC25B	P30305	YWHAE	Homo sapiens	P62258	Y2H	7644510
Intra	CDC25B	P30305	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CDC25B	P30305	YWHAB	Homo sapiens	P31946	Affinity Chrom	12871587
Intra	CDC25B	P30305	YWHAB	Homo sapiens	P31946	CoIP	16672277
Intra	CDC25B	P30305	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	26496610
Intra	CDC25B	P30305	YWHAB	Homo sapiens	P31946	Y2H	7644510
Intra	CDC25B	P30305	YWHAB	Homo sapiens	P31946	Y2H	10713667
Intra	CDC25B	P30305	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC25B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80072	Cdc25B Antibody	WB, IP, IF-Tissue	Human, Mouse

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108543	NSC 95397		99.0%	Unkown
HY-100034	NSC 663284	Inhibitor	99.29%	Unkown
HY-135457	JMS-053	Inhibitor	98.0%	Unkown
HY-132578	M5N36	Inhibitor	98.00%	Unkown
HY-112776A	BN82002 hydrochloride	Inhibitor	99.36%	Unkown
HY-121065	BN-82685	Inhibitor	99.05%	Unkown
HY-128769	M2N12	Inhibitor	98.19%	Unkown
HY-151986	FOXM1-IN-1	Inhibitor	99.86%	Unkown
HY-126246	CDC25B-IN-1	Inhibitor	98.12%	Unkown
HY-137175A	CDC25B-IN-2	Inhibitor	97.02%	Unkown
HY-P11228	FPP29		99.20%	Unkown
HY-W024644	Hydroxyethylthio Vitamine K3		≥97.0%	Unkown
HY-W102931	6,7-Dichloroquinoline-5,8-dione	Inhibitor	98.26%	Unkown
HY-112776	BN82002	Inhibitor	/	Unkown
HY-118529	JUN-1111	Inhibitor	98.57%	Unkown
HY-135564B	(Rac)-RK-682	Inhibitor	/	Unkown
HY-137990	Questin	Inhibitor	97.75%	Unkown
HY-172807	p38α-IN-9	Inhibitor	/	Unkown
HY-175033	BRD4-IN-11	Inhibitor	/	Unkown
HY-181011	PROTAC Cdc25 degrader-1		/	Unkown
HY-182285	5-HT7 modulator-1		/	Unkown
HY-182285A	5-HT7 modulator-1 hydrochloride		/	Unkown
HY-28086	CDC25-IN-2	Inhibitor	/	Unkown
HY-N12177	Cryptosporioptide A	Inhibitor	/	Unkown
HY-RS02292	CDC25B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N19821	Gangaleoidin	Inhibitor	/	Unkown
HY-RS19767	Cdc25b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26264	Cdc25b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDC25B	MGD	MGI:99701
Macaca mulatta	CDC25B	VGNC	VGNC:70795
Felis catus	CDC25B	VGNC	VGNC:60650
Bos taurus	CDC25B	VGNC	VGNC:27063
Rattus norvegicus	CDC25B	RGD	RGD:621500
Canis familiaris	CDC25B	VGNC	VGNC:38990
Others	CDC25B	NCBI