6,7-Dichloroquinoline-5,8-dione
Based on 1 Customer Validation
6,7-Dichloroquinoline-5,8-dione (compound DA3002) is a potent CDC25B2 inhibitor with an IC50 value of 4.6 µM. 6,7-Dichloroquinoline-5,8-dione has the potential for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 98.26%
- CAS No.: 6541-19-1
- Formula: C9H3Cl2NO2
- Molecular Weight:228.03
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 4.6 µM (CDC25B2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C32 | IC50 |
22.72 μM
Compound: 1
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Cytotoxicity against human C32 cells harboring low levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human C32 cells harboring low levels of NQO1 after 72 hrs by WST1 assay
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[PMID: 28006669] |
| CEM-SS | CC50 |
1 μM
Compound: 81047
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Cytotoxicity in human CEM-SS cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in human CEM-SS cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 27663546] |
| HEK-293T | CC50 |
17 μM
Compound: 81047
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Cytotoxicity in HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 27663546] |
| HFF-1 | IC50 |
15.66 μM
Compound: 1
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Cytotoxicity against HFF1 after 72 hrs by WST1 assay
Cytotoxicity against HFF1 after 72 hrs by WST1 assay
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[PMID: 28006669] |
| HL-60 | IC50 |
31.8 μM
Compound: 7a
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Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
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[PMID: 20363637] |
| MCF7 | IC50 |
22.5 μM
Compound: 1
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Cytotoxicity against human MCF7 cells harboring high levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human MCF7 cells harboring high levels of NQO1 after 72 hrs by WST1 assay
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[PMID: 28006669] |
| MDA-MB-231 | IC50 |
24.96 μM
Compound: 1
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Cytotoxicity against human MDA-MB-231 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human MDA-MB-231 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
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[PMID: 28006669] |
| MT4 | CC50 |
2 μM
Compound: 81047
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Cytotoxicity in human MT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in human MT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 27663546] |
| Neutrophil | IC50 |
1.3 μM
Compound: 7a
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Antiinflammatory activity in human neutrophils assessed as inhibition of PMA-induced superoxide production after 20 mins by WST1 assay
Antiinflammatory activity in human neutrophils assessed as inhibition of PMA-induced superoxide production after 20 mins by WST1 assay
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[PMID: 20363637] |
| SNB-19 | IC50 |
26.1 μM
Compound: 1
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Cytotoxicity against human SNB19 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human SNB19 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
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[PMID: 28006669] |
| T-cell | IC50 |
32.9 μM
Compound: 7a
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Antiproliferative activity against human T cells after 48 hrs by MTT assay
Antiproliferative activity against human T cells after 48 hrs by MTT assay
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[PMID: 20363637] |
Chemical Information
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CAS No. 6541-19-1
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Appearance Solid
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Molecular Weight 228.03
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Formula C9H3Cl2NO2
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Color Light green to green
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SMILES
C1=CN=C2C(=C1)C(=O)C(=C(C2=O)Cl)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 25 mg/mL (109.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3854 mL | 21.9269 mL | 43.8539 mL | 109.6347 mL |
| 5 mM | 0.8771 mL | 4.3854 mL | 8.7708 mL | 21.9269 mL | |
| 10 mM | 0.4385 mL | 2.1927 mL | 4.3854 mL | 10.9635 mL | |
| 15 mM | 0.2924 mL | 1.4618 mL | 2.9236 mL | 7.3090 mL | |
| 20 mM | 0.2193 mL | 1.0963 mL | 2.1927 mL | 5.4817 mL | |
| 25 mM | 0.1754 mL | 0.8771 mL | 1.7542 mL | 4.3854 mL | |
| 30 mM | 0.1462 mL | 0.7309 mL | 1.4618 mL | 3.6545 mL | |
| 40 mM | 0.1096 mL | 0.5482 mL | 1.0963 mL | 2.7409 mL | |
| 50 mM | 0.0877 mL | 0.4385 mL | 0.8771 mL | 2.1927 mL | |
| 60 mM | 0.0731 mL | 0.3654 mL | 0.7309 mL | 1.8272 mL | |
| 80 mM | 0.0548 mL | 0.2741 mL | 0.5482 mL | 1.3704 mL | |
| 100 mM | 0.0439 mL | 0.2193 mL | 0.4385 mL | 1.0963 mL |
6,7-Dichloroquinoline-5,8-dione Related Classifications
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