Anticancer agent-369
Anticancer agent-369 is an anticancer agent. Anticancer agent-369 exhibits antiproliferative and cytotoxic activities against gastric cancer, hepatocellular carcinoma, and lung cancer cell lines. Anticancer agent-369 binds within the active pocket of the cell cycle phosphatase Cdc25B and forms hydrogen-bonding interactions with active site residues. Anticancer agent-369 can be used in research related to gastric cancer, liver cancer, and lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 2584415-31-4
- Formula: C19H13F2N7OS
- Molecular Weight:425.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MGC-803 | IC50 |
2.43 μM
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Antiproliferative activity against human gastric carcinoma MGC-803 cells assessed as viability reduction by MTT assay.
Antiproliferative activity against human gastric carcinoma MGC-803 cells assessed as viability reduction by MTT assay.
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41967614 |
| HepG2 | IC50 |
1.73 μM
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Antiproliferative activity against human hepatocellular carcinoma HepG2 cells assessed as viability reduction by MTT assay.
Antiproliferative activity against human hepatocellular carcinoma HepG2 cells assessed as viability reduction by MTT assay.
|
41967614 |
| PC-9 | IC50 |
4.03 μM
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Antiproliferative activity against human pulmonary carcinoma PC-9 cells assessed as viability reduction by MTT assay.
Antiproliferative activity against human pulmonary carcinoma PC-9 cells assessed as viability reduction by MTT assay.
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41967614 |
| HUVEC | IC50 |
34.62 μM
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Cytotoxicity against normal human umbilical vein endothelial HUVEC cells by MTT assay.
Cytotoxicity against normal human umbilical vein endothelial HUVEC cells by MTT assay.
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41967614 |
In Vitro
Anticancer agent-369, as shown by molecular docking studies, can embed into the active site of Cdc25B and form multiple hydrogen bonds with residues within this site[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2584415-31-4
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Molecular Weight 425.41
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Formula C19H13F2N7OS
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SMILES
O=C1N=C(NC2=C(F)C=CC=C2)C(NC3=CC=CC=C3F)=C/C1=N/NC4=NN=CS4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent-369 Related Classifications
HY-190607 Related Classifications
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