5-HT7 modulator-1

5-HT7 modulator-1 (Compound 36) binds strongly to the 5-HT₇ receptor expressed in HEK293 cells, with a K_i of 92 nM and a K_b of 11 nM^[1].
5-HT7 modulator-1 (0.1-315.5 μM; 24 h) potently inhibits proliferation of MDA-MB-468, MDA-MB-231, and Hs578T TNBC cells with IC₅₀ values of 7.1 μM, 11.3 μM, and 6.7 μM respectively, and shows limited cytotoxicity against NHDF cells with an IC₅₀ of 12.2 μM^[1].
5-HT7 modulator-1 (0.7-5.7 μM (MDA-MB-231); 0.8-6.7 μM (Hs578T); 7 days) dose-dependently suppresses long-term clonogenic growth of MDA-MB-231 and Hs578T TNBC cells^[1].
5-HT7 modulator-1 (1.5 × IC₅₀; 24 h) induces G₂/M phase cell cycle arrest in MDA-MB-231 TNBC cells^[1].
5-HT7 modulator-1 (16.95 μM; 24 h) suppresses FOXM1 activation and downstream G₂/M regulator expression (cyclin B1, cdc25B) in MDA-MB-231 TNBC cells after 24 h of treatment at 1.5 × IC₅₀^[1].
5-HT7 modulator-1 (0.5 × IC₅₀-2 × IC₅₀; 24 h) exhibits enhanced antiproliferative activity in MDA-MB-231 TNBC cells pretreated with Serotonin (HY-B1473A)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.