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JMS-053 

Cat. No.: HY-135457
Handling Instructions

JMS-053 is a potent, selective and reversible PTP4A inhibitor, with IC50s of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM, and 207.6 nM for PTP4A1, PTP4A2, PTP4A3, CDC25B, and DUSP3, respectively. JMS-053 can inhibit cancer cell migration and spheroid growth in vitro, attenuate in vivo ovarian tumor growth.

For research use only. We do not sell to patients.

JMS-053 Chemical Structure

JMS-053 Chemical Structure

CAS No. : 1954650-11-3

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Description

JMS-053 is a potent, selective and reversible PTP4A inhibitor, with IC50s of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM, and 207.6 nM for PTP4A1, PTP4A2, PTP4A3, CDC25B, and DUSP3, respectively. JMS-053 can inhibit cancer cell migration and spheroid growth in vitro, attenuate in vivo ovarian tumor growth[1].

IC50 & Target

IC50: 29.1 nM (PTP4A1), 48.0 nM (PTP4A2), 34.7 nM (PTP4A3), 92.6 nM (CDC25B), 207.6 nM (DUSP3)[1]

Molecular Weight

256.28

Formula

C13H8N2O2S

CAS No.
SMILES

O=C1C(C=C(C2=CC=CC=C2)S3)=C3C(C(N1)=O)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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JMS-053
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