1. Anti-infection
  2. Parasite
  3. CRK12-IN-2

CRK12-IN-2 

Cat. No.: HY-143322
Handling Instructions

CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis.

For research use only. We do not sell to patients.

CRK12-IN-2 Chemical Structure

CRK12-IN-2 Chemical Structure

CAS No. : 1990479-17-8

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Description

CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis[1].

In Vivo

CRK12-IN-2 (10 mg/kg; s.c. once daily for 4 days) effectively cures mice with T. congolense- and T. vivax-infection[1].
1.19 Pharmacokinetic Properties of CRK12-IN-2 in Cattle[1].

Cattle
IV 2 mg/kg
Cattle
IM 10 mg/kg
Clb (mL/min/kg) 15±5
Vdss (L/kg) 2.3±0.6
half-life (h) 4±2
AUC0-∞(ng·min/mL) 140000±40000 500000±30000
Cmax (ng/mL) 1700±800
Tmax (h) 1.3±0.6
F (%) 73±6

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with T. congolense and T. vivax infection[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; 10 mg/kg once daily; for 4 days
Result: Fully cured both T. congolense- and T. vivax-infected mice for 4 days at a dose of 10 mg/kg.
Molecular Weight

529.67

Formula

C23H33F2N5O3S2

CAS No.
SMILES

CC(CS(=O)(N[[email protected]]1CC[[email protected]@H](CC1)NC2=NC(N)=C(S2)C(C3=C(C=C(C=C3F)CN(C)C)F)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CRK12-IN-2
Cat. No.:
HY-143322
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