BICRA - BRD4 interacting chromatin remodeling complex associated protein Gene

Also Known as CSS12; GLTSCR1; SMARCK1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29998

About BICRA

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:47,608,196-47,703,277 (from NCBI)

This gene has 4 transcripts (splice variants), 183 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 1.9), prostate (RPKM 1.7) and 25 other tissues.

Summary

Enables transcription regulator activator activity. Involved in positive regulation of transcription, DNA-templated. Located in nucleus. Part of SWI/SNF complex. Implicated in Coffin-Siris syndrome. [provided by Alliance of Genome Resources, Apr 2022]

BICRA Products (2)

mRNA	Protein	Name
NM_001394372.1	NP_001381301.1	BRD4-interacting chromatin-remodeling complex-associated protein
NM_015711.3	NP_056526.3	BRD4-interacting chromatin-remodeling complex-associated protein

BICRA Protein Structure

GLTSCR1

0
300
600
900
1200
1560 a.a.

Protein Preferred Names	Protein Names
BRD4-interacting chromatin-remodeling complex-associated protein	BRD4 interacting chromatin remodelling complex associated protein

BICRA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BICRA	Q9NZM4	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	BICRA	Q9NZM4	CRK	Homo sapiens	P46108	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

BICRA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810026	GLTSCR1 Antibody (YA9370)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Coffin-Siris Syndrome 12	CSS12
Neuroma
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12
Hypertrichosis
Clark-Baraitser Syndrome	CLABARS Baraitser Syndrome Autosomal Dominant Intellectual Disability 49 Mental Retardation, Autosomal Dominant 49, Formerly Mrd49, Formerly Intellectual Developmental Disorder, Autosomal Dominant 49 Autosomal Dominant Mental Retardation 49 Intellectual Disability, Tall Stature, Obesity, Macrocephaly And Typical Facial Features Mrd49 Progeria Short Stature Pigmented Nevi

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01500	BICRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BICRA	VGNC	VGNC:38454
Felis catus	BICRA	VGNC	VGNC:82434
Mus musculus	BICRA	MGD	MGI:2154263
Bos taurus	BICRA	VGNC	VGNC:26494
Macaca mulatta	BICRA	VGNC	VGNC:70466
Rattus norvegicus	BICRA	RGD	RGD:1306385
Others	BICRA	NCBI