DOCK1 - dedicator of cytokinesis 1 Gene

Also Known as ced5; DOCK180

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1793

About DOCK1

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:126,905,428-127,452,516 (from NCBI)

This gene has 6 transcripts (splice variants), 226 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 10.9), skin (RPKM 10.0) and 24 other tissues.

Summary

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

DOCK1 Products (14)

mRNA	Protein	Name
NM_001290223.2	NP_001277152.2	dedicator of cytokinesis protein 1 isoform 1
NM_001377543.1	NP_001364472.1	dedicator of cytokinesis protein 1 isoform 3
NM_001377544.1	NP_001364473.1	dedicator of cytokinesis protein 1 isoform 4
NM_001377546.1	NP_001364475.1	dedicator of cytokinesis protein 1 isoform 5
NM_001377547.1	NP_001364476.1	dedicator of cytokinesis protein 1 isoform 6
NM_001377548.1	NP_001364477.1	dedicator of cytokinesis protein 1 isoform 7
NM_001377550.1	NP_001364479.1	dedicator of cytokinesis protein 1 isoform 8
NM_001377553.1	NP_001364482.1	dedicator of cytokinesis protein 1 isoform 9
NM_001377554.1	NP_001364483.1	dedicator of cytokinesis protein 1 isoform 10
NM_001377556.1	NP_001364485.1	dedicator of cytokinesis protein 1 isoform 11
NM_001377558.1	NP_001364487.1	dedicator of cytokinesis protein 1 isoform 12
NM_001377560.1	NP_001364489.1	dedicator of cytokinesis protein 1 isoform 13
NM_001377561.1	NP_001364490.1	dedicator of cytokinesis protein 1 isoform 14
NM_001380.5	NP_001371.2	dedicator of cytokinesis protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	12134158	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12134158	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	19004829	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	19004829	GOA
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	21900250	GOA
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	21900250	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17515907	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21900250	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21900250	GOA
part of guanyl-nucleotide exchange factor complex	IDA IDA: Inferred from direct assay	12134158	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	21900250	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	21900250	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK1 Protein Structure

SH3_9

DOCK-C2

DHR-2

0
300
600
900
1200
1500
1865 a.a.

Protein Preferred Names	Protein Names
dedicator of cytokinesis protein 1	180 kDa protein downstream of CRK

DOCK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DOCK1	Q14185	DOCK5	Homo sapiens	Q9H7D0-1	Anti Tag CoIP	32203420
Intra	DOCK1	Q14185	ELMO1	Homo sapiens	Q92556	Anti Tag CoIP	15247908
Intra	DOCK1	Q14185	ELMO1	Homo sapiens	Q92556	Pull Down	18768751
Intra	DOCK1	Q14185	ELMO1	Homo sapiens	Q92556	Anti Tag CoIP	12134158
Intra	DOCK1	Q14185	ELMO1	Homo sapiens	Q92556	Pull Down	15723800
Intra	DOCK1	Q14185	ELMO1	Homo sapiens	Q92556	Anti Tag CoIP	18768751
Intra	DOCK1	Q14185	ELMO1	Homo sapiens	Q92556	Anti Tag CoIP	15723800
Intra	DOCK1	Q14185	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	19118547
Intra	DOCK1	Q14185	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
Intra	DOCK1	Q14185	RAC1	Homo sapiens	P63000	Pull Down	12134158
Intra	DOCK1	Q14185	RAC1	Homo sapiens	P63000	Pull Down	15723800
Intra	DOCK1	Q14185	RAC1	Homo sapiens	P63000	Anti Tag CoIP	12134158

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chromosome 10q26 Deletion Syndrome	Distal 10q Deletion Syndrome Terminal Chromosome 10q26 Deletion Syndrome Distal Monosomy 10q Monosomy 10qter Telomeric Deletion 10q Distal Deletion 10q 10q26 Deletion Syndrome 10qter Deletion Telomeric Deletion 10
Immunodeficiency 40	Dock2 Deficiency IMD40 Immunodeficiency, Type 40
Spinocerebellar Ataxia, Autosomal Recessive 15	Autosomal Recessive Spinocerebellar Ataxia 15 SCAR15 Salih Ataxia Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Rubcn Deficiency Autosomal Recessive Spinocerebellar Ataxia Type 15 Spinocerebellar Ataxia, Autosomal Recessive, 15 Ataxia, Spinocerebellar, Autosomal Recessive, Type 15
Stereotypic Movement Disorder	Stereotypy Habit Disorder Stereotyped Repetitive Movements Stereotyped Disorder Stereotypes Nos Stereotype Habit Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136177	Tris(2,4-di-tert-butylphenyl)phosphate	Inhibitor	99.81%	Unkown
HY-124711	TBOPP	Inhibitor	99.35%	Unkown
HY-RS03921	DOCK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20911	Dock1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27428	Dock1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DOCK1	VGNC	VGNC:28154
Macaca mulatta	DOCK1	VGNC	VGNC:71965
Mus musculus	DOCK1	MGD	MGI:2429765
Rattus norvegicus	DOCK1	RGD	RGD:1566072
Felis catus	DOCK1	VGNC	VGNC:97403
Canis familiaris	DOCK1	VGNC	VGNC:40043
Others	DOCK1	NCBI