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TBOPP 

Cat. No.: HY-124711
Handling Instructions

TBOPP is a selective inhibitor of DOCK1 with an IC50 of 8.4 μM. TBOPP binds to the DOCK1 DHR-2 domain with high affinity (Kd of 7.1 μM), has anti-tumor activity for broader types of tumors.

For research use only. We do not sell to patients.

TBOPP Chemical Structure

TBOPP Chemical Structure

CAS No. : 1996629-79-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 486 In-stock
Estimated Time of Arrival: December 31
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
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100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TBOPP is a selective inhibitor of DOCK1 with an IC50 of 8.4 μM. TBOPP binds to the DOCK1 DHR-2 domain with high affinity (Kd of 7.1 μM), has anti-tumor activity for broader types of tumors[1].

IC50 & Target

IC50: 8.4 μM (DOCK1); Kd: 7.1 μM (DOCK1 DHR-2 domain)[1]

In Vitro

TBOPP (12.5 µM; 3 days; 3LL cells) treatment inhibits DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins[1].

Cell Viability Assay[1]

Cell Line: 3LL cells
Concentration: 12.5 µM
Incubation Time: 3 days
Result: Inhibited cell viability.
In Vivo

TBOPP (0.67 mg per mouse; administrated on days 0, 1, 3, and 5; for 2 weeks; C57BL/6 mice) treatment effectively suppresses metastasis of cancer cells in vivo and the number of lymphocytes in the spleen is not changed, the body weight is also unchanged between TBOPP-treated and non-treated mice[1].

Animal Model: C57BL/6 mice (6- to 8-week-old) with ex-3LL cells[1]
Dosage: 0.67 mg per mouse
Administration: Administrated on days 0, 1, 3, and 5; for 2 weeks
Result: The lung metastasis was significantly suppressed.
Molecular Weight

490.49

Formula

C₂₄H₂₁F₃N₂O₄S

CAS No.

1996629-79-8

SMILES

O=C1C=CC(S(=O)(N2CCCC2)=O)=CN1CC(C3=CC=C(C4=CC=CC(C(F)(F)F)=C4)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

TBOPPOthersInhibitorinhibitorinhibit

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