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  3. ELK3 - ETS transcription factor ELK3 Gene

ELK3 - ETS transcription factor ELK3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ERP; NET; SAP2; SAP-2

Gene ID: 2004 | Gene type: protein coding

About ELK3

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,194,375-96,269,824 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 22.8) and 24 other tissues.

Summary

This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

ELK3 Products(8)

mRNA Protein Name
NM_001303511.2 NP_001290440.1 ETS domain-containing protein Elk-3 isoform 2
NM_001413760.1 NP_001400689.1 ETS domain-containing protein Elk-3 isoform 1
NM_001413761.1 NP_001400690.1 ETS domain-containing protein Elk-3 isoform 1
NM_001413762.1 NP_001400691.1 ETS domain-containing protein Elk-3 isoform 3
NM_001413763.1 NP_001400692.1 ETS domain-containing protein Elk-3 isoform 4
NM_001413764.1 NP_001400693.1 ETS domain-containing protein Elk-3 isoform 5
NM_001413765.1 NP_001400694.1 ETS domain-containing protein Elk-3 isoform 6
NM_005230.4 NP_005221.2 ETS domain-containing protein Elk-3 isoform 1

ELK3 Protein Structure

Ets

Ets: Ets-domain (5 - 86)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
Protein Preferred Names Protein Names

ETS domain-containing protein Elk-3

ELK3, ETS transcription factor

Related Diseases

Diseases Alias
Yellow Nail Syndrome

Yns

Lymphedema And Yellow Nails

Lymphedema With Yellow Nails

Lymphedema-Yellow Nails

LYYN

Hereditary Lymphedema And Yellow Nails

Hereditary Lymphoedema And Yellow Nails
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107753 XRP44X Inhibitor 98.42% Unkown
HY-RS04306 ELK3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ELK3 VGNC VGNC:28433
Canis familiaris ELK3 VGNC VGNC:40304
Macaca mulatta ELK3 VGNC VGNC:72210
Felis catus ELK3 VGNC VGNC:61811
Rattus norvegicus ELK3 RGD RGD:1307764
Mus musculus ELK3 MGD MGI:101762