MAP4K1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

Also Known as HPK1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11184

About MAP4K1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,587,641-38,617,953 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 197 orthologues and 35 paralogues. Biased expression in lymph node (RPKM 28.4), spleen (RPKM 19.4) and 10 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MAP4K1 Products (3)

mRNA Protein Name
NM_007181.6 NP_009112.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform 2
XM_011526404.2 XP_011524706.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform X1
NM_001042600.3 NP_001036065.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
8824585 GOA
enables MAP kinase kinase kinase kinase activity IDA
IDA: Inferred from direct assay
11053428 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9346925 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8824585 GOA
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IDA
IDA: Inferred from direct assay
8824585 GOA
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
24362026 GOA
involved in cellular response to phorbol 13-acetate 12-myristate IDA
IDA: Inferred from direct assay
8824585 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
11053428 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
11053428 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
8824585 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
8824585 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP4K1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (17 - 273)

CNH

CNH: CNH domain (506 - 797)

  • 0
  • 200
  • 400
  • 600
  • 833 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 1

  • MAPK/ERK kinase kinase kinase 1

  • MEK kinase kinase 1

  • MEKKK 1

  • hematopoietic progenitor kinase 1

MAP4K1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP4K1 Q92918 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
Intra
MAP4K1 Q92918 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra
MAP4K1 Q92918 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
MAP4K1 Q92918 ABL1 Homo sapiens P00519
Peptide Array
17474147
Intra
MAP4K1 Q92918 ABL1 Homo sapiens P00519
Y2H
9346925
Intra
MAP4K1 Q92918 NCK1 Homo sapiens P16333
Pull Down
9346925
Intra
MAP4K1 Q92918 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
MAP4K1 Q92918 NCK1 Homo sapiens P16333
Y2H
9346925
Intra
MAP4K1 Q92918 GRB2 Homo sapiens P62993
Pull Down
9346925
Intra
MAP4K1 Q92918 GRB2 Homo sapiens P62993
SPR
9346925
Intra
MAP4K1 Q92918 GRB2 Homo sapiens P62993
Y2H
9346925
Intra
MAP4K1 Q92918 GRB2 Homo sapiens P62993
Pull Down
32707033
Intra
MAP4K1 Q92918 GRB2 Homo sapiens P62993
Anti Bait CoIP
9346925
Intra
MAP4K1 Q92918 SLAMF1 Homo sapiens Q13291
Pull Down
20231852
Intra
MAP4K1 Q92918 SLAMF1 Homo sapiens Q13291
Anti Bait CoIP
20231852
Intra
MAP4K1 Q92918 FYN Homo sapiens P06241
Peptide Array
17474147
Intra
MAP4K1 Q92918 PLCG1 Homo sapiens P19174
Anti Bait CoIP
17474147
Intra
MAP4K1 Q92918 PLCG1 Homo sapiens P19174
Fluorescence
17474147
Intra
MAP4K1 Q92918 PIK3R1 Homo sapiens P27986
Peptide Array
17474147
Intra
MAP4K1 Q92918 CRK Homo sapiens P46108
Peptide Array
17474147
Intra
MAP4K1 Q92918 CRKL Homo sapiens P46109
CoIP
9788432
Cross: Cross-species interaction Intra: Intraspecies interaction

MAP4K1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84713 MAP4K1 Antibody (YA4410) WB, IHC-P, FC, ELISA Human, Mouse, Monkey, Rat
HY-P84713A MAP4K1 Antibody (YA4410)(PBS only) WB, IHC-P, FC, ELISA Human, Mouse, Monkey, Rat

Related Diseases

Diseases Alias
Melnick-Needles Syndrome

  • MNS

  • Melnick-Needles Osteodysplasty

  • Osteodysplasty Of Melnick And Needles

  • Osteochondrodysplasias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138568 HPK1-IN-3 Inhibitor 98.61% Unkown
HY-138742 HPK1-IN-7 Inhibitor 99.11% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-149056 GNE-6893 Inhibitor 99.94% Unkown
HY-170443 PF-07265028 Inhibitor 98.04% Unkown
HY-143868 HPK1-IN-27 Inhibitor / Unkown
HY-143871 HPK1-IN-30 Inhibitor / Unkown
HY-156509 HPK1-IN-38 Inhibitor / Unkown
HY-169199 BAY-405 Inhibitor / Unkown
HY-RS08071 MAP4K1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08072 Map4k1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08073 Map4k1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160940 HPK1-IN-46 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAP4K1 MGD MGI:1346882
Bos taurus MAP4K1 VGNC VGNC:31204
Rattus norvegicus MAP4K1 RGD RGD:1305463
Felis catus MAP4K1 VGNC VGNC:97498
Canis familiaris MAP4K1 VGNC VGNC:42981
Others MAP4K1 NCBI