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Cat. No.: HY-162544

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PROTAC HPK1 Degrader-2

PROTAC HPK1 Degrader-2 (compound 3) is a PROTAC degrader of HPK1, with the DC₅₀ of 23 nM in human PBMC. PROTAC HPK1 Degrader-2 plays an important role in cancer research.
(Pink: HPK1 ligand (HY-162545); Blue: Cereblon ligand (HY-W761300); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2893885-31-7
Formula: C₄₃H₄₇N₉O₄
Molecular Weight:753.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PROTAC HPK1 Degrader-2 Chemical Structure

CAS No.: 2893885-31-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC HPK1 Degrader-2 (compound 3) is a PROTAC degrader of HPK1, with the DC₅₀ of 23 nM in human PBMC. PROTAC HPK1 Degrader-2 plays an important role in cancer research^[1]. (Pink: HPK1 ligand (HY-162545); Blue: Cereblon ligand (HY-W761300); Black: linker).

All PROTACs Isoforms :

All MAP4K Isoforms :

Chemical Information

CAS No. 2893885-31-7
Molecular Weight 753.89
Formula C₄₃H₄₇N₉O₄
SMILES

CC1=C2C(CCN(CCC(N3CCN(C4=CC=C(N5C(NC(CC5)=O)=O)C=C4)CC3)=O)C2)=CC(C6=NC(C(C7=CC=C(C(N(C)C)=O)C(C)=C7)=CN8)=C8N=C6)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. BeiGene, Ltd. Preparation of pyrrolo[2,3-b]pyrazine-based bifunctional compounds as HPK1 degraders and the use thereof. World Intellectual Property Organization, WO2023006063 A1 2023-02-02.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PROTAC HPK1 Degrader-2

All PROTACs Isoforms

All MAP4K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC HPK1 Degrader-2 Related Classifications

HY-162544 Related Classifications