2. Stem Cell/Wnt
  3. Porcupine Wnt
  4. IWP-O1

IWP-O1 

Cat. No.: HY-100853 Purity: 99.61%
COA Handling Instructions

IWP-O1 est un inhibiteur très puissant de Porc-épic (Porcn), avec un EC50 de 80 pM dans les cellules L-Wnt-STF. IWP-O1 empêche la sécrétion des protéines Wnt. IWP-O1 supprime la phosphorylation de Dvl2/3 et LRP6 dans les cellules HeLa.

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.

For research use only. We do not sell to patients.

IWP-O1 Chemical Structure

IWP-O1 Chemical Structure

CAS No. : 2074607-48-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 132 In-stock
Solid
1 mg USD 57 In-stock
5 mg USD 120 In-stock
10 mg USD 210 In-stock
25 mg USD 450 In-stock
50 mg USD 810 In-stock
100 mg USD 1450 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

IWP-O1 Related Antibodies

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Description

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells[1].

IC50 & Target

EC50: 80 pM (Porcn)[1].
In Vitro

IWP-O1 (17) suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM, 2.5 times more active than the investigational drug LGK974[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IWP-O1 Related Antibodies
Molecular Weight

432.48

Appearance

Solid

Formula

C26H20N6O
CAS No.
SMILES

O=C(CN1N=NC(C2=CC=NC=C2)=C1C3=CC=CC=C3)NC4=NC=C(C5=CC=CC=C5)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (289.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3122 mL 11.5612 mL 23.1225 mL
5 mM 0.4624 mL 2.3122 mL 4.6245 mL
10 mM 0.2312 mL 1.1561 mL 2.3122 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.81 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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IWP-O1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

IWP-O12074607-48-8PorcupineWntInhibitorinhibitorinhibit

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