DACT1 - dishevelled binding antagonist of beta catenin 1 Gene

Also Known as DPR1; TBS2; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51339

About DACT1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:58,634,061-58,648,321 (from NCBI)

This gene has 6 transcripts (splice variants), 193 orthologues, 2 paralogues and is associated with 5 phenotypes. Broad expression in gall bladder (RPKM 10.6), ovary (RPKM 9.1) and 22 other tissues.

Summary

The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

DACT1 Products (2)

mRNA	Protein	Name
NM_001079520.2	NP_001072988.1	dapper homolog 1 isoform 2
NM_016651.6	NP_057735.2	dapper homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18936100	GOA
enables beta-catenin binding	IDA IDA: Inferred from direct assay	18936100	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	18936100	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	18936100	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16446366	GOA
enables protein kinase A binding	IDA IDA: Inferred from direct assay	21262972	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	18936100	GOA
involved in negative regulation of JNK cascade	IDA IDA: Inferred from direct assay	17197390	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	16446366	GOA
acts upstream of or within negative regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16446366	GOA
involved in negative regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18936100	GOA
involved in negative regulation of beta-catenin-TCF complex assembly	IDA IDA: Inferred from direct assay	18936100	GOA
involved in negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18936100	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22610794	GOA
involved in negative regulation of protein binding	IGI IGI: Inferred from genetic interaction	18936100	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18936100	GOA
involved in neural tube development	IMP IMP: Inferred from mutant phenotype	22610794	GOA
involved in positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	21262972	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15580286	GOA
involved in positive regulation of protein binding	IGI IGI: Inferred from genetic interaction	18936100	GOA
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	16446366	GOA
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	16446366	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	18936100	GOA
involved in regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18936100	GOA
NOT involved in regulation of nodal signaling pathway	IDA IDA: Inferred from direct assay	17197390	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	21262972	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	22470507	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16446366	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18936100	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DACT1 Protein Structure

Dapper

0
200
400
600
836 a.a.

Protein Preferred Names	Protein Names
dapper homolog 1	dapper antagonist of catenin 1

DACT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DACT1	Q9NYF0	GSK3B	Homo sapiens	P49841	Anti Bait CoIP	22470507
Intra	DACT1	Q9NYF0	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	22470507
Intra	DACT1	Q9NYF0	DVL2	Homo sapiens	O14641	Imaging	16446366
Intra	DACT1	Q9NYF0	DVL2	Homo sapiens	O14641	Anti Bait CoIP	16446366
Intra	DACT1	Q9NYF0	DVL2	Homo sapiens	O14641	Anti Tag CoIP	16446366

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Townes-Brocks Syndrome 2	TBS2
Craniorachischisis	Anencephaly With Rachischisis
Townes-Brocks Syndrome	Townes Syndrome Renal-Ear-Anal-Radial Syndrome Anus, Imperforate, With Hand, Foot And Ear Anomalies Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome Rear Syndrome Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs Tbs Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs Imperforate Anus With Hand, Foot And Ear Anomalies Anal-Ear-Renal-Radial Malformation Syndrome Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Imperforate Anus-Hand And Foot Anomalies Syndrome Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs
Occipital Encephalocele
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Myelomeningocele	Meningomyelocele
Epiphyseal Dysplasia, Multiple, With Myopia And Conductive Deafness	Multiple Epiphyseal Dysplasia, Beighton Type EDMMD Epiphyseal Dysplasia, Multiple, With Myopia And Deafness Multiple Epiphyseal Dysplasia With Myopia And Deafness Multiple Epiphyseal Dysplasia-Myopia-Deafness Syndrome Multiple Epiphyseal Dysplasia-Myopia-Hearing Loss Syndrome Multiple Epiphyseal Dysplasia With Myopia And Conductive Deafness Dysplasia, Epiphyseal, Multiple, With Myopia And Deafness
Intestinal Disaccharidase Deficiency	Disaccharidase Deficiency
Anencephaly	Aprosencephaly Anencephalus Congenital Absence Of Brain Absence Of A Large Part Of The Brain And The Skull Anencephalia Anencephalic Monster Brain Absence Brain Agenesis Brain Aplasia Absent Brain Anencephalic Congenital Absence Of Cerebrum Congenital Hemicrania Incomplete Anencephaly
Orange Allergy	Citrus Sinensis Fruit Allergy
Deafness, Autosomal Recessive 100	DFNB100 Autosomal Recessive Nonsyndromic Deafness 100 Autosomal Recessive Deafness 100 Deafness, Autosomal Recessive, 100
Ectodermal Dysplasia 5, Hair/Nail Type	ECTD5 Ectodermal Dysplasia 5
Ectodermal Dysplasia 6, Hair/Nail Type	ECTD6 Ectodermal Dysplasia 6
Ectodermal Dysplasia 7, Hair/Nail Type	ECTD7 Ectodermal Dysplasia 7 Dysplasia, Ectodermal, Type 7, Hair/Nail
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
17-Beta Hydroxysteroid Dehydrogenase Iii Deficiency	17-Ksr Deficiency Neutral 17-Beta-Hydroxysteroid Oxidoreductase Deficiency Pseudohermaphroditism, Male, With Gynecomastia 17-Beta Hydroxysteroid Dehydrogenase 3 Deficiency Testosterone 17-Beta-Dehydrogenase Deficiency 17-Ketosteroid Reductase Deficiency Of Testis 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency 17-Ketoreductase Deficiency 17-Ketosteroidreductase Deficiency 46,Xy Disorder Of Sex Development Due To 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency Male Pseudohermaphroditism With Gynecomastia 17 Alpha Ksr Deficiency 17 Alpha Ketosteroid Reductase Deficiency Of Testis 17 Beta Hydroxysteroid Dehydrogenase Iii Deficiency Male Pseudoherma-Phroditism With Gynecomastia Neutral 17 Beta Hydroxysteroid Oxidoreductase Deficiency Male Pseudohermaphrodism With Gynecomastia MPH 17-Hydroxysteroid Dehydrogenase Deficiency
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03515	DACT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DACT1	MGD	MGI:1891740
Bos taurus	DACT1	VGNC	VGNC:27867
Felis catus	DACT1	VGNC	VGNC:104383
Canis familiaris	DACT1	VGNC	VGNC:39761
Macaca mulatta	DACT1	VGNC	VGNC:71650
Rattus norvegicus	DACT1	RGD	RGD:1564008
Others	DACT1	NCBI