Pard6a - par-6 family cell polarity regulator alpha Gene

Also Known as Par6; Par-6; Par6c; TAX40; PAR-6A; Tip-40; PAR6alpha; 0710008C04Rik; 2610010A15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56513

Summary

Enables GTP-dependent protein binding activity and small GTPase binding activity. Involved in cell-cell junction maintenance and positive regulation of protein secretion. Acts upstream of or within negative regulation of protein phosphorylation. Located in several cellular components, including apical part of cell; bicellular tight junction; and cell cortex. Is expressed in several structures, including 2-cell stage conceptus; brain; gut; lung; and reproductive system. Orthologous to human PARD6A (par-6 family cell polarity regulator alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pard6a Products (5)

mRNA Protein Name
NM_001047435.2 NP_001040900.1 partitioning defective 6 homolog alpha isoform 2
NM_001047436.2 NP_001040901.1 partitioning defective 6 homolog alpha isoform 3
NM_001286344.1 NP_001273273.1 partitioning defective 6 homolog alpha isoform 4
NM_001286345.1 NP_001273274.1 partitioning defective 6 homolog alpha isoform 5
NM_019695.3 NP_062669.2 partitioning defective 6 homolog alpha isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP-dependent protein binding IPI
IPI: Inferred from physical interaction
10954424 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10954424 MGI
enables small GTPase binding IDA
IDA: Inferred from direct assay
10954424 MGI
Biological Process GO Annotation Evidence References Source
involved in cell-cell junction maintenance IDA
IDA: Inferred from direct assay
10954424 MGI
acts upstream of or within negative regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
24305805 MGI
involved in positive regulation of protein secretion IMP
IMP: Inferred from mutant phenotype
27044754 MGI
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
10954424 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
15028215 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
14685273 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10954424 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

partitioning defective 6 homolog alpha

  • PAR-6 alpha

  • Tax interaction protein 40

  • par-6 (partitioning defective 6,) homolog alpha

Pard6a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Pard6a Q9Z101 DVL2 Homo sapiens O14641
Anti Tag CoIP
19379695
Cross
Pard6a Q9Z101 DVL2 Homo sapiens O14641
Lumier
19379695
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10038 PARD6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pard6a NCBI NCBI:50855