PARD6A - par-6 family cell polarity regulator alpha Gene

Also Known as PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50855

About PARD6A

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,660,960-67,662,774 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 2 paralogues. Broad expression in testis (RPKM 9.8), brain (RPKM 5.0) and 23 other tissues.

Summary

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

PARD6A Products (2)

mRNA Protein Name
NM_001037281.2 NP_001032358.1 partitioning defective 6 homolog alpha isoform 2
NM_016948.3 NP_058644.1 partitioning defective 6 homolog alpha isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10934474 GOA
Biological Process GO Annotation Evidence References Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
20719959 GOA
involved in establishment or maintenance of epithelial cell apical/basal polarity IDA
IDA: Inferred from direct assay
11257119 GOA
involved in positive regulation of protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
20719959 GOA
Cellular Component GO Annotation Evidence References Source
part of PAR polarity complex IPI
IPI: Inferred from physical interaction
11257119 GOA
located in centriolar satellite IDA
IDA: Inferred from direct assay
20719959 GOA
located in centrosome IDA
IDA: Inferred from direct assay
20719959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARD6A Protein Structure

PB1

PB1: PB1 domain (16 - 94)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (158 - 246)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

partitioning defective 6 homolog alpha

  • PAR-6 alpha

PARD6A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PARD6A Q9NPB6 PRKCI Homo sapiens P41743
Y2H
11257119
Intra
PARD6A Q9NPB6 PRKCI Homo sapiens P41743
Y2H
21516116
Intra
PARD6A Q9NPB6 PRKCI Homo sapiens P41743
Validated Y2H
25416956
Intra
PARD6A Q9NPB6 PRKCI Homo sapiens P41743
Anti Tag CoIP
26496610
Intra
PARD6A Q9NPB6 PRKCI Homo sapiens P41743
Y2H Array
25416956
Intra
PARD6A Q9NPB6 PRKCI Homo sapiens P41743
Anti Bait CoIP
17057644
Intra
PARD6A Q9NPB6 PRKCI Homo sapiens P41743
Anti Tag CoIP
14676191
Intra
PARD6A Q9NPB6 PRKCI Homo sapiens P41743
CoIP
11257119
Intra
PARD6A Q9NPB6 PRKCI Homo sapiens P41743
X-Ray Diffraction
15590654
Intra
PARD6A Q9NPB6 CDH5 Homo sapiens P33151
Pull Down
17057644
Intra
PARD6A Q9NPB6 CDH5 Homo sapiens P33151
Anti Bait CoIP
17057644
Intra
PARD6A Q9NPB6 PRKCZ Homo sapiens Q05513
Anti Tag CoIP
17350623
Intra
PARD6A Q9NPB6 PRKCZ Homo sapiens Q05513
Imaging
17057644
Intra
PARD6A Q9NPB6 PRKCZ Homo sapiens Q05513
Anti Tag CoIP
14676191
Intra
PARD6A Q9NPB6 CDC42 Homo sapiens P60953
Pull Down
11260256
Intra
PARD6A Q9NPB6 CDC42 Homo sapiens P60953
Anti Tag CoIP
14676191
Intra
PARD6A Q9NPB6 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
14676191
Intra
PARD6A Q9NPB6 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
26496610
Intra
PARD6A Q9NPB6 PARD3 Homo sapiens Q8TEW0
CoIP
11257119
Cross: Cross-species interaction Intra: Intraspecies interaction

PARD6A Antibodies

Cat. No. Product Name Application Reactivity
HY-P81791 PAR6 Antibody (YA1536) WB, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10038 PARD6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PARD6A VGNC VGNC:44265
Mus musculus PARD6A MGD MGI:1927223
Rattus norvegicus PARD6A RGD RGD:1303273
Felis catus PARD6A VGNC VGNC:64041
Bos taurus PARD6A VGNC VGNC:32583
Macaca mulatta PARD6A VGNC VGNC:104743
Others PARD6A NCBI