PRKCZ - protein kinase C zeta Gene

Also Known as PKC2; PKC-ZETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5590

About PRKCZ

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:2,048,504-2,185,395 (from NCBI)

This gene has 26 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 11.4), placenta (RPKM 8.8) and 22 other tissues.

Summary

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from Other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PRKCZ Products (35)

mRNA Protein Name
NR_146911.2
XM_017001789.2 XP_016857278.1 protein kinase C zeta type isoform X1
XM_024448396.2 XP_024304164.1 protein kinase C zeta type isoform X14
XM_011541776.2 XP_011540078.1 protein kinase C zeta type isoform X14
XR_007061965.1
XR_007061966.1
XM_017001803.3 XP_016857292.1 protein kinase C zeta type isoform X18
XM_024448397.2 XP_024304165.1 protein kinase C zeta type isoform X16
NM_001350805.2 NP_001337734.1 protein kinase C zeta type isoform 5
XM_017001793.2 XP_016857282.1 protein kinase C zeta type isoform X10
XM_047425273.1 XP_047281229.1 protein kinase C zeta type isoform X7
XM_047425260.1 XP_047281216.1 protein kinase C zeta type isoform X5
XM_047425262.1 XP_047281218.1 protein kinase C zeta type isoform X6
XM_011541775.4 XP_011540077.1 protein kinase C zeta type isoform X13
XM_047425304.1 XP_047281260.1 protein kinase C zeta type isoform X10
XM_017001802.2 XP_016857291.1 protein kinase C zeta type isoform X17
NM_001242874.3 NP_001229803.1 protein kinase C zeta type isoform 3
XM_017001797.2 XP_016857286.1 protein kinase C zeta type isoform X12
XM_047425348.1 XP_047281304.1 protein kinase C zeta type isoform X15
NM_001350803.2 NP_001337732.1 protein kinase C zeta type isoform 4
XM_047425323.1 XP_047281279.1 protein kinase C zeta type isoform X11
XM_024448391.2 XP_024304159.1 protein kinase C zeta type isoform X10
XM_017001792.2 XP_016857281.1 protein kinase C zeta type isoform X10
XM_017001790.2 XP_016857279.1 protein kinase C zeta type isoform X2
XM_047425307.1 XP_047281263.1 protein kinase C zeta type isoform X10
XM_011541773.2 XP_011540075.1 protein kinase C zeta type isoform X3
XM_047425340.1 XP_047281296.1 protein kinase C zeta type isoform X14
XM_047425255.1 XP_047281211.1 protein kinase C zeta type isoform X4
XM_011541774.2 XP_011540076.1 protein kinase C zeta type isoform X8
XM_047425283.1 XP_047281239.1 protein kinase C zeta type isoform X9
NM_001033581.3 NP_001028753.1 protein kinase C zeta type isoform 2
NM_001350806.2 NP_001337735.1 protein kinase C zeta type isoform 5
NM_001033582.3 NP_001028754.1 protein kinase C zeta type isoform 2
NM_002744.6 NP_002735.3 protein kinase C zeta type isoform 1
NM_001350804.2 NP_001337733.1 protein kinase C zeta type isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables diacylglycerol-dependent serine/threonine kinase activity EXP
EXP: Inferred from Experiment
12391145 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10831594 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
10770950 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15069075 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15069075 GOA
involved in negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
15069075 GOA
involved in negative regulation of protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
15069075 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
15069075 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
11035106 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10770950 GOA
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
20332120 GOA
located in vesicle IDA
IDA: Inferred from direct assay
17313651 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCZ Protein Structure

PB1

PB1: PB1 domain (16 - 97)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (131 - 182)

Pkinase

Pkinase: Protein kinase domain (253 - 503)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (540 - 583)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
Protein Preferred Names Protein Names

protein kinase C zeta type

  • nPKC-zeta

PRKCZ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRKCZ Q05513 AGER Homo sapiens Q15109
Anti Bait CoIP
21829704
Intra
PRKCZ Q05513 PRKCI Homo sapiens P41743
Anti Tag CoIP
33961781
Intra
PRKCZ Q05513 PRKCI Homo sapiens P41743
Anti Bait CoIP
24375676
Intra
PRKCZ Q05513 PRKCI Homo sapiens P41743
CoIP
11260256
Intra
PRKCZ Q05513 PRKCI Homo sapiens P41743
Anti Tag CoIP
28514442
Intra
PRKCZ Q05513 PRKCI Homo sapiens P41743
Pull Down
32707033
Intra
PRKCZ Q05513 PRKCI Homo sapiens P41743
Anti Tag CoIP
25852190
Intra
PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Pull Down
32707033
Intra
PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
CoIP
11260256
Intra
PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Validated Y2H
27107012
Intra
PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Y2H
11260256
Intra
PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Anti Tag CoIP
31980649
Intra
PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
BFG-2H
27107012
Intra
PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Validated Y2H
32296183
Intra
PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Anti Tag CoIP
25852190
Intra
PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
17057644
Intra
PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
31980649
Intra
PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
25852190
Intra
PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
33961781
Intra
PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Pull Down
32707033
Intra
PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
28514442
Intra
PRKCZ Q05513 AKT1 Homo sapiens P31749
Anti Bait CoIP
18650932
Intra
PRKCZ Q05513 VHL Homo sapiens P40337
Anti Tag CoIP
17350623
Intra
PRKCZ Q05513 C1QBP Homo sapiens Q07021
Anti Tag CoIP
25852190
Intra
PRKCZ Q05513 C1QBP Homo sapiens Q07021
Anti Tag CoIP
31980649
Intra
PRKCZ Q05513 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
22939624
Intra
PRKCZ Q05513 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
PRKCZ Q05513 PRKCQ Homo sapiens Q04759
Anti Bait CoIP
17588663
Intra
PRKCZ Q05513 PRKCQ Homo sapiens Q04759
Protein Kinase Assay
17588663
Intra
PRKCZ Q05513 NCF1 Homo sapiens P14598
Pull Down
27040869
Intra
PRKCZ Q05513 NCF1 Homo sapiens P14598
Anti Bait CoIP
27040869
Intra
PRKCZ Q05513 NUMB Homo sapiens P49757-1
Anti Tag CoIP
17203073
Intra
PRKCZ Q05513 NUMB Homo sapiens P49757-1
Pull Down
17203073
Intra
PRKCZ Q05513 NUMB Homo sapiens P49757-1
Protein Kinase Assay
17203073
Intra
PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Anti Tag CoIP
17057644
Intra
PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Y2H
11260256
Intra
PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Anti Tag CoIP
25852190
Intra
PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Anti Tag CoIP
33961781
Intra
PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Y2H Pooling
16189514
Intra
PRKCZ Q05513 BCL10 Homo sapiens O95999
Anti Bait CoIP
25011391
Intra
PRKCZ Q05513 BCL10 Homo sapiens O95999
PLA
25011391
Intra
PRKCZ Q05513 BCL10 Homo sapiens O95999
Confocal
25011391
Cross
PRKCZ Q05513 numb Drosophila melanogaster P16554
Protein Kinase Assay
17203073
Cross: Cross-species interaction Intra: Intraspecies interaction

PRKCZ Antibodies

Cat. No. Product Name Application Reactivity
HY-P80280 Phospho-PKC zeta (Thr560) Antibody (YA162) WB, IHC-P Human, Mouse
HY-P82886A Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631)(PBS only) WB, IHC-P Human, Mouse
HY-P82934 Phospho-PKC zeta (Thr560) Antibody (YA2679) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Diabetes Mellitus

  • Diabetes
Combined Oxidative Phosphorylation Deficiency 33

  • COXPD33
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Chromosome 1p36 Deletion Syndrome

  • 1p36 Deletion Syndrome

  • Deletion 1p36

  • Monosomy 1p36

  • Subtelomeric 1p36 Deletion

  • Monosomy 1p36 Syndrome

  • Distal Monosomy 1p36

  • Del(1)(P36)

  • Deletion 1pter

  • Monosomy 1pter
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Diabetes Mellitus, Non-Insulin-Dependent

  • Type 2 Diabetes

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11141 PRKCZ Human Pre-designed siRNA Set A / Unkown
HY-RS11142 Prkcz Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11143 Prkcz Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PRKCZ VGNC VGNC:33336
Felis catus PRKCZ VGNC VGNC:80323
Mus musculus PRKCZ MGD MGI:97602
Macaca mulatta PRKCZ VGNC VGNC:82212
Rattus norvegicus PRKCZ RGD RGD:3399
Canis familiaris PRKCZ VGNC VGNC:44985
Others PRKCZ NCBI