PRKCQ - protein kinase C theta Gene

Also Known as PRKCT; nPKC-theta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5588

About PRKCQ

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:6,394,097-6,580,646 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 5 paralogues. Broad expression in thyroid (RPKM 4.0), lymph node (RPKM 2.9) and 17 other tissues.

Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

PRKCQ Products (9)

mRNA	Protein	Name
NM_001323267.2	NP_001310196.1	protein kinase C theta type isoform 5
NM_001323265.1	NP_001310194.1	protein kinase C theta type isoform 1
NM_006257.5	NP_006248.1	protein kinase C theta type isoform 1
NM_001282645.1	NP_001269574.1	protein kinase C theta type isoform 4
XM_005252496.5	XP_005252553.1	protein kinase C theta type isoform X1
NM_001242413.2	NP_001229342.1	protein kinase C theta type isoform 2
XM_005252497.5	XP_005252554.1	protein kinase C theta type isoform X2
NM_001282644.2	NP_001269573.1	protein kinase C theta type isoform 3
NM_001323266.2	NP_001310195.1	protein kinase C theta type isoform 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: Inferred from Experiment	16356856	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10383400	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	34593629	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	24008408	GOA
involved in negative regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11342610	GOA
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15364919	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16356855	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	34593629	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCQ Protein Structure

C1_1

Pkinase

Pkinase_C

0
200
400
600
706 a.a.

Protein Preferred Names	Protein Names
protein kinase C theta type

PRKCQ Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRKCQ	Q04759	LCK	Homo sapiens	P06239	Anti Tag CoIP	21964608
Intra	PRKCQ	Q04759	MAP4K3	Homo sapiens	Q8IVH8	Pull Down	21983831
Intra	PRKCQ	Q04759	PRKCZ	Homo sapiens	Q05513	Y2H	17588663
Intra	PRKCQ	Q04759	GLRX3	Homo sapiens	O76003	CoIP	10636891
Intra	PRKCQ	Q04759	GLRX3	Homo sapiens	O76003	Pull Down	10636891
Intra	PRKCQ	Q04759	FYN	Homo sapiens	P06241	Protein Kinase Assay	10383400
Intra	PRKCQ	Q04759	FYN	Homo sapiens	P06241	Pull Down	10383400
Intra	PRKCQ	Q04759	FYN	Homo sapiens	P06241	Y2H	10383400
Intra	PRKCQ	Q04759	HSF1	Homo sapiens	Q00613	Anti Bait CoIP	23352416
Cross	PRKCQ	Q04759	Irs1	Rattus norvegicus	P35570	Protein Kinase Assay	23352416

Cross: Cross-species interaction Intra: Intraspecies interaction

PRKCQ Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81361	PKC theta Antibody (YA1106)	IHC-P	Human
HY-P81361A	PKC theta Antibody (YA1106)(PBS only)	IHC-P	Human
HY-P83417	PKC theta Antibody (YA3162)	WB	Human, Rat
HY-P83417A	PKC theta Antibody (YA3162)(PBS only)	WB	Human, Rat

Related Diseases

Diseases	Alias
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Ciliary Dyskinesia, Primary, 20	Primary Ciliary Dyskinesia 20 CILD20 Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus Ics20 Immotile Cilia Syndrome 20 Dyskinesia, Ciliary, Primary, 20
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Enteritis, Granulomatous Crohn'S Disease Of Colon Granulomatous Colitis Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Enteritis Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS11137	PRKCQ Human Pre-designed siRNA Set A	/	Unkown
HY-RS11138	Prkcq Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11139	Prkcq Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKCQ	MGD	MGI:97601
Felis catus	PRKCQ	VGNC	VGNC:69067
Canis familiaris	PRKCQ	VGNC	VGNC:44983
Rattus norvegicus	PRKCQ	RGD	RGD:620968
Macaca mulatta	PRKCQ	VGNC	VGNC:76416
Bos taurus	PRKCQ	VGNC	VGNC:33334
Others	PRKCQ	NCBI