MAP4K3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

Also Known as GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8491

About MAP4K3

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:39,249,266-39,437,285 (from NCBI)

This gene has 13 transcripts (splice variants), 211 orthologues and 35 paralogues. Ubiquitous expression in thyroid (RPKM 14.7), testis (RPKM 13.3) and 25 other tissues.

Summary

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

MAP4K3 Products (7)

mRNA Protein Name
NM_003618.4 NP_003609.2 mitogen-activated protein kinase kinase kinase kinase 3 isoform 1
XM_024453183.2 XP_024308951.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X4
XM_047446093.1 XP_047302049.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X3
NM_001410753.1 NP_001397682.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 3
XM_047446092.1 XP_047302048.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X2
XM_047446091.1 XP_047302047.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X1
NM_001270425.2 NP_001257354.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9275185 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9275185 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9275185 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9275185 GOA
involved in response to UV IDA
IDA: Inferred from direct assay
9275185 GOA
involved in response to tumor necrosis factor IDA
IDA: Inferred from direct assay
9275185 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP4K3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (16 - 273)

CNH

CNH: CNH domain (567 - 864)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 894 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 3

  • MAPK/ERK kinase kinase kinase 3

  • MEK kinase kinase 3

  • germinal center kinase-like kinase

  • germinal center kinase-related protein kinase

MAP4K3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP4K3 Q8IVH8 MAP4K5 Homo sapiens Q9Y4K4
Pull Down
32707033
Intra
MAP4K3 Q8IVH8 MAP4K5 Homo sapiens Q9Y4K4
Anti Tag CoIP
33961781
Cross
MAP4K3 Q8IVH8 Prkcq Mus musculus Q02111
Anti Tag CoIP
21983831
Intra
MAP4K3 Q8IVH8 LCP2 Homo sapiens Q13094
Anti Tag CoIP
21983831
Intra
MAP4K3 Q8IVH8 LCP2 Homo sapiens Q13094
Anti Bait CoIP
21983831
Intra
MAP4K3 Q8IVH8 PRKCQ Homo sapiens Q04759
Anti Tag CoIP
21983831
Cross: Cross-species interaction Intra: Intraspecies interaction

MAP4K3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810827 GLK Antibody (YA10070) WB, IHC-P Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-RS08077 MAP4K3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08078 Map4k3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08079 Map4k3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAP4K3 RGD RGD:621280
Felis catus MAP4K3 VGNC VGNC:81117
Mus musculus MAP4K3 MGD MGI:2154405
Macaca mulatta MAP4K3 VGNC VGNC:81466
Bos taurus MAP4K3 VGNC VGNC:31206
Canis familiaris MAP4K3 VGNC VGNC:42983
Others MAP4K3 NCBI